Abstract: OBJECTIVE   To explore the effects and mechanisms of drug moxibustion along the sectional Ren channel on the semen parameters of oligospermia.METHODS   70 patients were randomly divided into the treatment group and the control group, 35 cases per group. Vitamin E capsules and Wuzi Yanzong pills were given orally in the control group. Based on the control group, the treatment group adopted the Long-snake drug moxibustion along the sectional Ren channel. Semen parameters, semen superoxide dismutase (SOD) activity, levels of acetaldehyde (MDA), and DNA fragmentation index (DFI) in the two groups were analyzed before and after 2 or 3 months of treatment. Besides, clinical efficacy had been estimated.RESULTS   After treatment, sperm concentration and sperm vitality increased significantly in the two groups (P < 0.01). The tendencies of increased sperm concentration and improved normal form rate and sperm motility in the treatment group were obvious (P < 0.01). Compared with the control group, the treatment group had more effectively increased the SOD activity of the pulp, reduced the level of MDA, and decreased the DFI index (P < 0.01). The total clinical efficiency of the treatment group was 88.57%, higher than the control group (P < 0.05).CONCLUSION   Drug moxibustion along the sectional Ren channel can significantly reduce MDA level, increase SOD activity, improve DFI, optimize semen parameters, and improve clinical efficacy.