Abstract: The security of Chinese medicine has been increasingly concerned by the community. Centering on the significance of Chinese medicine incompatibility in the modernization of traditional Chinese medicine, the paper stood on abundant history and practical experience, analyzed the ancient and modern literature and clinical situation, combined with technology methods suitable for Chinese medicine incompatibility and experimental verification, clarified the properties of incompatibility, principle of using the advantages and avoiding the disadvantages, features of incompatible Chinese medicine in one prescription in certainly compatible environment. Literature retrieval-clinical analysis-experimental verification-deepened understanding research mode has certain reference significance on Chinese medicine incompatibility.