Abstract: Radiation-induced skin injury (RISI) is a common complication of tumor radiotherapy, for which modern medicine lacks effective preventive and therapeutic measures. Based on the pathogenesis theory of “excessive fire consumes qi”, combined with collateral disease theory and academic thought of Menghe School. Professor Huo Jiege holds that radiation is an exogenous “excessive fire” pathogen, whose pathogenic process follows the dynamic evolution law of heat toxin injuring yin-consuming qi and damaging yang-yang deficiency with blood stasis-phlegm and blood stasis binding. The acute stage of RISI is mainly characterized by intense heat toxin accompanied by qi and yin consumption, while the chronic stage is centered on yang deficiency with phlegm and blood stasis binding. Professor Huo Jiege established the “clearing-warming-unblocking stasis” therapy accordingly: the clearing method clears heat and purges fire, cools blood and detoxifies; the warming method warms yang and tonifies qi, strengthens body resistance and consolidates the root; the stasis-unblocking method dredges collaterals and dissipates blood stasis. The three methods are dynamically compatible and used in mutual restraint according to the course of disease, achieving the effects of clearing heat without injuring healthy qi, warming yang without assisting fire, and resolving stasis to dredge collaterals. This therapy constructs an integrated system of theory, method, formula and medicine for TCM prevention and treatment of RISI, providing theoretical basis and practical strategies for clinical diagnosis and treatment.