Abstract: Exogenous febrile diseases are characterized by sudden onset and rapid transmission, necessitating proactive intervention to prevent further progression. The intercepting and reversing strategy emphasizes predictive diagnosis and proactive treatment, aiming to interrupt the causative factors and reverse the disease trajectory through early and potent measures, thereby breaking the chain of disease transmission. Based on this theory, this article systematically reviews the pathogenetic evolution of exogenous febrile diseases centered on the sequential interplay of heat, phlegm, stasis, and deficiency. In the initial stage, intense heat consumes body fluids; subsequently, heat congeals fluids and blood, leading to the interlocking of phlegm and stasis; then phlegm and stasis generate further pathological changes, stirring wind and blocking the orifices; in the terminal stage, healthy qi is depleted while pathogenic factors linger, resulting in protracted and recurrent illness. In response to this pathogenetic chain, a stepwise intervention strategy is proposed: expelling pathogens and protecting yin to block transmission, simultaneously resolving phlegm and stasis to dissolve their cohesion, dredging collaterals and calming wind to prevent complications, and reinforcing healthy qi while dispelling pathogens to eliminate residual evils. This multilayer, interlocking approach elevates the therapeutic paradigm from “intercepting based on manifest symptoms” to “preemptive interception based on pathogenetic mechanisms”, providing an integrated pattern differentiation and treatment system for the clinical management of exogenous febrile diseases throughout their entire course.