姜黄素微乳凝胶治疗放疗后皮肤纤维化的临床研究
Clinical Research of Curcumin Microemulsion Gel on Skin Fibrosis after Radiotherapy
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摘要: 目的 探讨姜黄素微乳凝胶治疗放疗后皮肤纤维化的疗效及其对纤维化指标因子的影响。方法 选取2017年3月-2018年12月在南京中医药大学附属医院肿瘤科确诊的80例肿瘤放疗后皮肤纤维化患者，设姜黄素微乳凝胶为治疗组，积雪苷霜软膏为对照组，每天皮肤给药2次，连续2个月。考察对比2组患者的总有效率、西医评分、中医证候评分及纤维化因子的表达。结果 治疗后治疗组总有效率为92.5%，优于对照组的77.5%（P<0.05）；2组西医疗效评分明显改善（P<0.05），治疗组在改善关节痛方面显著优于对照组（P<0.05）；2组中医证候评分改善（P<0.05），治疗组皮肤变硬、肢体麻木症状较对照组改善明显（P<0.05）；2组血清纤维化因子羟脯氨酸（HYP）、转化生长因子-β（TGF-β）、结缔组织生长因子（CTGF）水平均显著下降（P<0.01），治疗组血清TGF-β和CTGF含量较对照组下降明显（P<0.05）。结论 姜黄素微乳凝胶治疗放疗后皮肤纤维化疗效显著，能明显降低患者血液中的纤维化因子水平。Abstract: OBJECTIVE To explore the curative effect of curcumin microemulsion gel on skin fibrosis after radiotherapy and the effect for fibrosis index factors. METHODS 80 patients with skin fibrosis diagnosed after tumor radiotherapy from March 2017 to December 2018 in the Department of Oncology of Affiliated Hospital of Nanjing university of Chinese medicine were selected. Curcumin microemulsion gel was set as the treatment group and asiaticoside cream was set as the control group， with 2 times daily skin administration for 2 consecutive months. The total effective rate， western medicine score， traditional Chinese medicine (TCM) syndrome score and expression of fibrosis factor in the two groups were compared. RESULTS After treatment， the total effective rate of the treatment group was 92.5%， better than 77.5% in the control group(P<0.05). Two groups of western medicine treatment efficacy scores were significantly improved (P<0.05). The treatment group was significantly better than the control group in improving the arthralgia (P<0.05). 2 groups of TCM syndrome evaluations were improved (P<0.05). The skin of the treatment group was hard and the symptoms of limb numbness were better than those of the control group (P<0.05). The serum fibrinization factor hydroxyproline (HYP)， transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) of the two groups all decreased significantly (P<0.01). The contents of TGF-β and CTGF in blood serum of treatment group were significantly lower than those of control group (P<0.05). CONCLUSION Curcumin microemulsion gel treatment has significant effects on skin fibrosis after radiotherapy， and reduces the levels of fibrosis factor in patients' blood significantly.
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Key words:
- curcumin /
- microemulsion gel /
- radiotherapy /
- skin fibrosis /
- fibrosis factor
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[1] TERRAZZINO S， DEANTONIO L， CARGNIN S， et al. DNA methyltransferase gene polymorphisms for prediction of radiation-induced skin fibrosis after treatment of breast cancer: A multifactorial genetic approach[J]. Cancer Res Treat， 2017， 49(2):464-472. [2] 〖JP2〗KUMAR R， GRIFFIN M， ADIGBLI G， et al. Lipotransfer for radiation-induced skin fibrosis[J]. Br J Surg， 2016， 103(8):950-961.〖JP〗 [3] ANDREWS JP， MARTTALA J， MACARAK E， et al. Keloids: The paradigm of skin fibrosis-pathomechanisms and treatment[J]. Matrix Biol， 2016，51:37-46. [4] 韩桂香，李庆荣，朱萱萱.姜黄素抗纤维化作用的研究进展[J].西南国防医药，2016，26(1):102-104. [5] VAUGHN AR， HAAS KN， BURNEY W， et al. Potential role of curcumin against biofilm-producing organisms on the skin: A review[J]. Phytother Res， 2017，31(12):1807-1816. [6] 韩桂香，刘嘉，朱萱萱，等.姜黄素微乳凝胶抗皮肤纤维化作用的实验研究[J].江苏中医药，2018，50(8):75-78. [7] 〖JP2〗杨雪，王久存，吴文育，等.2013年美国风湿病学会/欧洲抗风湿联盟系统性硬化分类标准评析[J].上海医学，2014，37(2):101-104.〖JP〗 [8] 国家中医药管理局.中药新药临床研究指导原则（试行）[S].北京:中国医药科技出版社，2002:384. [9] 中华中医药学会.中医皮肤科常见病诊疗指南[M].北京:中国中医药出版社，2012:360. [10] 李智超，郭夏，王石，等.积雪草苷片口服联合地龙提取液外洗治疗局限性硬皮病疗效及对S100A8、S100A9的影响[J].现代中西医结合杂志，2018，27(30):3340-3343. [11] 贾谊君，吴克瑾.放疗后皮肤纤维化发生机制的研究进展[J].实用医学杂志，2013，29(10):1547-1548. [12] 杨欢欢.红花水煎液内服对硬皮小鼠皮肤纤维化影响的实验研究[D].南宁：广西医科大学，2014. [13] BEN YEHUDA GREENWALD M， FRUSIC-ZLOTKIN M， SOROKA Y， et al. Curcumin protects skin against UVB-induced cytotoxicity via the Keap1-Nrf2 pathway: the use of a microemulsion delivery system[J]. Oxid Med Cell Longev， 2017， 2017: 5205471. [14] 沈豪，郭霜，刘秀芬，等.TGF-β/Smads信号通路在姜黄素改善糖尿病大鼠心肌纤维化中的作用[J].中国药理学通报，2018， 34(4):522-527. -
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