芩丹胶囊对自发性高血压大鼠血管重构以及骨桥蛋白基因表达的影响

王博 张继东 冯进波 刘粉叶 尹慧秋

芩丹胶囊对自发性高血压大鼠血管重构以及骨桥蛋白基因表达的影响

王博张继东冯进波刘粉叶尹慧秋

[1]山东大学齐鲁医院, 山东济南250012 [2]山东大学齐鲁医院心血管功能与重构教育部重点实验室, 山东济南250012

基金项目: 山东省中医管理局科研基金资助项目（1-60）

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出版历程
- 收稿日期: 2007-01-03
- 刊出日期: 2007-05-10

Effect of Lingdan Capsule on Vascular Remodeling and Expression of Osteopontin Gene of Rats with Spontaneous Hypertension

摘要

摘要: 目的观察芩丹胶囊（QC）对自发性高血压大鼠（SHR）的降压作用及对血管重构的影响并探讨其可能的机制。方法SHRs随机分为模型组和QC组，WKY大鼠作为正常对照组。QC组给予芩丹胶囊灌胃治疗，模型组和正常对照组给予等量生理盐水。观测各组大鼠收缩压、主动脉中膜厚度（MT）、腔内径（LD）、MT／LD、中膜胶原含量以及中膜血管平滑肌细胞（VSMC）超微结构变化，实时定量PCR检测管壁骨桥蛋白（OPN）mRNA的表达。结果与模型组相比，QC组收缩压明显下降；主动脉MT、MT／LD以及中膜胶原含量均显著下降；主动脉壁VSMCs表型变化不明显；动脉壁OPNmRNA表达显著降低。结论QC不仅能够有效地降低SHRs血压，而且能够对动脉血管重构具有明显地逆转作用，其机制可能与下调血管OPNmRNA表达，进而抑制VSMCs表型的变化以及抑制血管壁胶原网络重构有关。

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参考文献(16)

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