Research Progress on Anti-Tumor Effect of Ligustrazine in Digestive System Neoplasms

Digestive system neoplasms remain a major threat to residents' health in our country， with the second highest morbidity and mortality in China. Therefore， there is an urgent need for developing safe and effective anti-tumor drugs. The anti-tumor effect of plant extracts has gradually become a research focus. A growing attention has been paid to anti-cancer effects of Ligustrazine， which is the effective component of Chuanxiong. We reviewed the anti-neoplastic effect of Ligustrazine from the aspects of proliferation， apoptosis， metastasis， invasion and reversion of chemotherapy resistance in neoplasms of digestive system， providing a theoretical basis and foundation for further exploring the anti-cancer mechanisms of Ligustrazine and promoting the clinical application.