Research Progress of GProtein Coupled Receptor MrgprD and its Implications for the Research of Chinese Medicine

Traditional Chinese medicine has the advantages of small side effects and clear curative effect in relieving itching and analgesia， but the molecular biological mechanisms are not clear. MrgprD (Mas-related gene D) is a member of the G-protein coupled receptor and is mainly expressed on peripheral primary sensory neurons. The study revealed the mechanism of involvement of MrgprD in neuropathic pain and discussed the relationship between itch and pain. Based on our own research results， we reviewed the current research status of MrgprD in recent decades. This review could provide a reference for the understanding of the function of MrgprD and the treatment of related diseases. Additionally， MrgprD may be the targets of antipruritic and analgesic Chinese herb and provide a new idea for the research of Chinese medicine.