Mechanism of Jinshui Liujun Decoction in the Treatment of Chronic Obstructive Pulmonary Disease Based on Network Pharmacology

OBJECTIVE To explore the mechanism of Jinshui Liujun decoction in the treatment of chronic obstructive pulmonary disease (COPD) by network pharmacology. METHODS The chemical ingredients and corresponding targets of Jinshui Liujun decoction were retrieved from TCMSP platform. The relevant targets of COPD were obtained through the TTD， DisGeNET， GeneCardsand and CTD databases， the targets of drug chemical ingredients were mapped to the targets of COPD. The intersection targets and the efficacy components were obtained. Using STRING database and Cytoscape 3.7.2 software， component-target network model was constructed. The OmicShare open platform was used to perform gene function (GO) and the Kyoto Gene and Genome Encyclopedia (KEGG) enrichment analysis. RESULTS Jinshui Liujun decoction had 96 intersection targets for COPD， 435 efficacy components (The main components are quercetin， stigmasterol， kaempferol， β-sitosterol， naringin， ursolic acid， etc.)， and 20 key targets which degree，betweenness and closeness are greater than average， including MAPK3， TNF， PPAR-γ， SIRTI， HMOX1， MAPK8， CAT， SIRT1， STAT3， etc. Enrichment analysis showed that the formula mainly involved the response to biological and chemical stimuli， various cell biological processes， cell proliferation， immunity， metabolism， etc. 17 signaling pathways including IL-17， Toll-like receptor， TNF， HIF-1， FoxO， TGF-β and ErbB， etc. play a role in the treatment of COPD. CONCLUSION Jinshui Liujun decoction can treat COPD through the synergy of multiple ingredients， multiple targets and multiple pathways， which provides basic data for in-depth exploration of the mechanism of Jinshui Liu jun decoction in the treatment of COPD.