Effects of Huazhuo Jiedu Formula on Chronic Atrophic Gastritis Patients with Helicobacter Pylori<\i> Infection

OBJECTIVE To observe the Helicobacter pylori(Hp) eradication rate and clinical effect of Huazhuo Jiedu Formula in the treatment of chronic atrophic gastritis (CAG) with Hp infection， and to explore its possible mechanism. METHODS 120 patients of CAG with Hp infection were randomly divided into two groups: the treatment group and the control group. The treatment group was given one dose of Huazhuo Jiedu formula per day， while the control group was given standard quadruple bactericidal therapy for 2 weeks， followed by placebo， one dose per day. After 3 months' treatment， TCM syndrome score， gastroscope mucosal symptom score， pathological tissue change score， gastrin-17 (G-17)， serum pepsinogen Ⅰ， Ⅱ (PGⅠ， PGⅡ)， PGⅠ/PG Ⅱ ratio (PGR)， cytotoxin associated protein (CagA)， vacuole cytotoxin (VacA) and urease B (UreB) of the two groups were compared before and after treatment. The eradication rate of HP was recorded before treatment， 6 weeks and 3 months after treatment， and after the follow-up for 6 months to observe the recurrence of Hp. RESULTS After three months' treatment， TCM syndrome scores in the two groups were significantly lower than those before treatment with significant difference (P<0.05， P<0.01)， compared with the control group (P<0.05， P<0.01). Compared with the control group， the gastroscope mucosal symptom score and pathological tissue change score in the treatment group were lower than those before treatment (P<0.05， P<0.01)， compared with the control group (P<0.05， P<0.01). The levels of PGⅠ and PGR in the treatment group were higher than those before treatment， and the levels of PG Ⅱ and G-17 were lower than those before treatment (P<0.05， P<0.01)， compared with the control group (P<0.05， P<0.01). The positive rates of CagA， VacA and UreB in the two groups were significantly lower than those before treatment (P<0.01)， compared with the control group (P<0.05， P<0.01). The eradication rate of Hp of patients in the treatment group was better than that in the control group (P<0.05). The 6 months follow-up recurrence rate of the treatment group was lower than that of the control group (P<0.01). CONCLUSION Huazhuo Jiedu formula， having good effect on Hp inhibition and low recurrence rate， is effective in the treatment of CAG with Hp infection. It can effectively alleviate clinical symptoms， improve pathological changes and promote mucosal repair. Its mechanism may be related to the levels of CagA， VacA， UreB， PGⅠ， PGⅡ， PGR and G-17.