Systematic Evaluation on the Effect of Chinese Medicine Formula on the Intervention of Liver Injury Induced by Anti-Tuberculosis Chemotherapy

OBJECTIVE To systematically evaluate the efficacy of Chinese medicine formula in the intervention of liver injury induced by anti-tuberculosis chemotherapy. METHODS CNKI， VIP， Wanfang Data and Pub Med databases were searched to collect randomized controlled trial (RCT) of Chinese medicine formula in intervention of liver injury induced by anti-tuberculosis chemotherapy from inception to the first of March 1， 2019. Two reviewers independently screened literature， extracted data and assessed the risk of bias of included studies. Meta-analysis was then performed by RevMan 5.3 software. RESULTS A total of 17 RCTs involving 1 410 patients with liver injury caused by anti-tuberculosis chemotherapy were included. The results showed that compared to the conventional treatment to protecting liver， intervention with Chinese medicine formula could significantly improve the effective rate RR=1.83，95%CI(1.50，2.23)，P<0.01， and its serum glutamic pyruvic transaminase (ALT) MD=-50.38，95%CI(-54.17，-46.58)，P<0.01， glutamic oxalacetic transaminase (AST)MD=-61.65，95%CI(-72.68，-50.61)，P<0.01， and total bilirubin (TBiL) MD=-11.02，95%CI(-13.24，-8.79)，P<0.01 were all better. CONCLUSION Current evidence shows that Chinese medicine formula is more conducive to reduce and control the occurrence of liver injury in the course of anti-tuberculosis treatment. It is of great significance to ensure that tuberculosis patients take drugs regularly， control their condition and complete the anti-tuberculosis treatment program.