Clinical Study of Guanxin Decoction in the Treatment of Residual Lesions Angina Pectoris After Percutaneous Coronary Intervention in Coronary Heart Disease Patients with Qi Deficiency and Blood Stasis Pattern

OBJECTIVE To observe the clinical effect of Guanxin Decoction in the treatment of residual lesions angina pectoris after percutaneous coronary intervention (PCI) in Percutaneous Coronary Intervention (CHD) patients with qi deficiency and blood stasis pattern. METHODS 100 CHD patients of qi deficiency and blood stasis pattern with residual lesions angina pectoris after PCI were randomly divided into the control group and Guanxin Decoction group. The control group (50 cases) was given conventional Western medicine， like aspirin， clopidogrel， atorvastatin calcium， metoprolol， isosorbide mononitrate， while Guanxin Decoction group (50 cases) was added with Guanxin Decoction on the basis of control group therapy. The therapeutic course was 3 months. The levels of hypersensitive C-reactive protein (hs-CRP)， lipid metabolism (TC， HDL-C， LDL-C) and total ischemia burden (TIB) were compared before and after treatment. The integral quality of life (SF-36)， recurrence rate and degree of angina pectoris， Seattle angina questionnaire (SAQ) and TCM syndrome scores were observed. The results were analyzed by SPSS 20.0. RESULTS The recurrence rate and degree of angina， SAQ， SF-36 and TCM syndrome scores of the two groups were improved after treatment (P<0.05， P<0.01)， and the effect of Guanxin Decoction group was better than that of the control group (P<0.05， P<0.01). The levels of hs-CRP， TC and LDL-C in the two groups were lower than those before treatment (P<0.05， P<0.01)， and the effect of Guanxin Decoction group was much more significant (P<0.05， P<0.01). The level of HDL-C in the two groups was higher than that before treatment (P<0.05)， but there was no difference between the two groups (P>0.05). The level of TIB in the two groups were lower than before (P<0.05， P<0.01)， and the decrease in Guanxin Decoction group was more significant (P<0.05). CONCLUSION Guanxin Decoction can effectively improve the clinical effect in treating residual lesions angina pectoris after PCI in CHD patients with qi deficiency and blood stasis syndrome， relieving myocardial ischemia， regulating blood lipid metabolism， reducing inflammatory response， and improving patients' quality of life.