Clinical Study on Treating Kidney Deficiency Type Sterility of Ovulation Disturbance with Menstrual Regulation Methods

OBJECTIVE To treat sterility of ovulation disturbance due to deficiency of kidney yin or kidney yang， this paper applied menstrual cycle regulation with Chinese medicine methods， syndrome differentiation and treatment methods and combination methods according to scientific efficacy evaluation system. Based on the comparison of large sample cohort and summary of efficacy， it has been proposed that regulating menstrual cycle with Chinese medicine to treat kidney deficiency type (including kidney yin or kidney yang) sterility of ovulation disturbance was effective. METHODS Female patients with sterility of ovulation disturbance were divided into three groups and given different treating methods respectively: menstrual cycle regulation with Chinese medicine group (115 cases， including 75 cases of kidney yang deficiency and 40 cases of kidney yin deficiency)， syndrome differentiation and treatment group (106 cases， including 52 cases of kidney yang deficiency and 54 cases of kidney yin deficiency) and combined treatment group (108 cases， including 60 cases of kidney yang deficiency and 48 cases of kidney yin deficiency). One course lasted three menstrual cycles. After four courses， clinical pregnancy rate， ovulation rate， menstrual symptom score， syndrome integral of three groups would be compared. RESULTS For patients with kidney yang deficiency type sterility of ovulation disturbance， clinical pregnancy rates of the three groups were 62.67%， 59.26% and 63.33% and ovulation rates were 67.43%， 53.21% and 65.31% in turn. Ovulation rates of menstrual regulation group and combined treatment group were significantly higher than that of syndrome differentiation group (P<0.01). After four courses， there were no significant differences among theses three groups in terms of syndrome integral while menstrual symptom scores of syndrome differentiation group and combined treatment group were significantly lower than that of menstrual regulation group (P<0.05). As to patients with kidney yin deficiency type sterility of ovulation disturbance， clinical pregnancy rates of the three groups were 65.00%， 53.85% and 62.50% and ovulation rates were 79.70%， 51.03% and 77.97% in turn. Ovulation rates of menstrual regulation group and combined treatment group were significantly higher than that of syndrome differentiation group (P<0.01). After four courses， there were no significant differences among theses three groups in terms of menstrual symptom score and syndrome integral while syndrome integrals of menstrual regulation group and combined treatment group were significantly lower than that of syndrome differentiation group (P<0.01). CONCLUSION Under the guidance of regulation of reproduction rhythm theory in traditional Chinese medicine， menstrual regulation methods have a positive therapeutic effect on treating sterility of ovulation disturbance， which can promote ovulation and increase pregnancy rate.