Analysis of Drug Use Rule of Breast Cancer in Ancient Literature Based on Association Rules and Complex Network

OBJECTIVE To explore the drug use rule of breast cancer in ancient medical literature on the basis of association rules and complex network. METHODS XMinerV2.4 was used to mold Fp-Growth algorithm for correlation analysis of prescription data， and weighted directed graph was used to represent the compatibility relationship between drugs. LiquoriceV3.0 was used to model the complex Net-work for network analysis of drugs， and the network nodes were analyzed for community aggregation， and the community structure was used to express the drug compatibility relationship. RESULTS 136 cases of oral prescriptions and 41 cases of external prescriptions were collected. The core drugs of the oral administration are e zhu (Rhizoma Curcumae)， bai zhu (angelica) and dang gui (Radix Angelicae Sensis). The compatibility of e zhu (Rhizoma Curcumae) includes san leng (Rhizoma Sparganii) - e zhu (Rhizoma Curcumae)， e zhu (Rhizoma Curcumae) - yin yang huo (Herba Epimedii)， e zhu (Rhizoma Curcumae)- lu jiao pian (Cornu Cervi Tablets)， e zhu (Rhizoma Curcumae) - rou cong rong (Cistanchis Herba)， and e zhu (Rhizoma Curcumae)- gou qi zi (Fructus Lycii). The compatibility of dang gui (Radix Angelicae Sensis) is: dang gui (Radix Angelicae Sensis) - ren shen (Ginseng)， dang gui (Radix Angelicae Sensis) - fangfeng (Divaricate Saposhnikovia)， dang gui (Radix Angelicae Sensis) - shu di (Rehmannia Glutinosa); The compatibility of bai zhu (Angelica) is: bai zhu (Angelica) - shijianchuan， bai zhu (Angelica) - nan sha shen (Glehnia Root) and bai zhu (Angelica) - gou qi zi (Fructus Lycii). The correlation between ku fan (Dried Alum) and bai zhi (Angelica Dahurica) is the highest among the external medicines， and at the same time， jiang can (Bombyx Batryticatus) is the main medicine， forming different medicine pairs or groups such as jiang can (Bombyx Batryticatus) - qiang huo (Notopterygium Root)， jiang can (Bombyx Batryticatus) - （chuan wu (monkshood)， qiang huo (Notopterygium Root))， jiang can (Bombyx Batryticatus) - xiang fu (Nutgrass Galingale Rhizome)， etc. Through complex network analysis， it can be seen that the core drug group in the oral prescription is beneficial to warming yang and activating blood: dang shen (Radix Codonopsis)， bai zhu (Rhizoma Atractylodis Macrocephalae)， huang qi (Radix Astragali)， fu ling (Poria)， yin yang huo (Herba Epimedii)， rou cong rong (Herba Cistanches)， yan hu suo (Rhizoma Corydalis)， e zhu (Rhizoma Curcumae)， shan zhu yu (Fructus Corni); Nourishing yin and resolve toxin: nan sha shen (Radix Adenophorae)， gou qi zi (Fructus Lycii)， shi jian chuan (Radix Clematidis)， and lu feng fang (Nidus Vespae); Moving qi and activating blood herbs: dang gui (angelica)， yu jin (Curcuma Aromatica) and xiang fu (Nutgrass Galingale Rhizome); Dissolving phlegm and quickening blood herbs: san leng (Sparganium)， tao ren (Peach Kernel)， lu jiao pian (Cornu Cervi Slice)， dan shen (Salvia Miltiorrhiza)， yan hu suo (Rhizoma Corydalis) and hai zao (Seaweed). The compatibility analysis outside the core drugs suggested that there were drug pairs such as kun bu (Kelp) - mu li (Oyster)， bai jie zi (Mustard Seed) - lu jiao jiao (Antler Glue)， zhi qiao (Bitter Orange) - hou po (Magnolia Bark)， xuan shen (Figwort) - bai lian (Ampelopsis)， etc. The core medicine in the external prescription is the antidote for promoting blood circulation and removing yang: dang gui (Radix Angelicae Sinensis)， bai lian (Radix Ampelopsis)， mo yao (Myrrha)， ru xiang (Olibanum)， cong bai (Bulbus Allii Fistulosi)， xing ren (Semen Armeniacae Amarum)， bi ma ren (Castor Bean) and hong hua (Flos Carthami). Analysis of compatibility outside the core drugs suggests that there are pain relievers for promoting blood circulation and warming the interior: dang gui (Radix Angelicae Sinensis)， chuan xiong (Rhizoma Chuanxiong)， cao wu (Radix Aconiti Kusnezoffii); Dispersing wind medicine: jiang can (Bombyx Batryticatus)， qiang huo (Rhizoma et Radix Notopterygii); Resolving Phlegm and moving qi herbs: zhi qiao (Fructus Aurantii)， xiang fu (Rhizoma Cyperi)， chen pi (Pericarpium Citri Reticulatae)， ban xia (Rhizoma Pinelliae)， etc. CONCLUSION Using association rules and complex network methods to analyze the drug use rules of breast cancer in ancient literature can provide a reference for exploring the pathogenesis and clinical treatment of the disease in ancient times， expand the treatment thinking of contemporary clinicians， and combine the analysis results to use the typical drug pairs， especially those rare in contemporary clinical practice， when the conventional treatment for breast cancer recurrence and metastasis is ineffective， thus providing ideas and directions for modern clinical research of breast cancer.