Clinical Effects Observation on Conbercept Injection Combining with Self-made Tonify Qi and Induce Diuresis Decoction for Macular Edema after Phacoemulsification Surgery in Diabetic Patients

OBJECTIVE To investigate the clinical effects of intravitreal injection of conbercept combined with self-made tonify qi and induce diuresis decoction for macular edema after phacoemulsification surgery in diabetic patients. METHODS 92 diabetic patients (92 eyes) with macular edema after 3 months of phacoemulsification surgery visited our hospital from 2015 to 2017 were enrolled， among which 44 patients (44 eyes) had diabetes but without diabetic retinopathy (group A)， and 48 patients (48 eyes) had diabetes with non-proliferative diabetic retinopathy (group B). Patients in group A and group B were randomly divided into the control group and the treatment group. Intravitreal injection of conbercept were given to the control group (group A， 22 eyes; group B， 24 eyes) for 1 time/month. And after treated for three months continuously， to repeat the treatment or not should be based on the disease condition. On the basis of the control group， intravitreal injection of conbercept combined with self-made tonify qi and induce diuresis decoction were given to the treatment group (group A， 22 eyes; group B， 24 eyes)， 1 decoction/day， 3 months were taken as one course. The best corrected visual acuity (BCVA)， changes of intraocular pressure and central macular retinal thickness (CMT) before the treatment and 1-month， 3-month and 6-month after the treatment were observed， and the occurrence of complications was also observed. RESULTS Before the treatment， the differences of BCVA and CMT between each group had no statistical significance (P>0.05). The BCVA and CMT at 1-month， 3-month and 6-month after the treatment in in two groups were significantly improved than those of the pre-treatment， and the difference was statistically significant (P<0.05). The differences of BCVA and CMT in the control A and the treatment A group， the control B group and the treatment B group at each postoperative time point were statistically significant (P<0.05). The CMT differences between the treatment B group and the treatment A group after 3 months and 6 months of treatment had statistical significance (P<0.05). After the treatment， the intraocular pressures in each group were normal and no serious complications occurred. CONCLUSIONS Intravitreal injection of conbercept combined with self-made tonify qi and induce diuresis decoction is effective for diabetic patients with macular edema after phacoemulsification surgery， which can obviously improve visual acuity and relieve macular edema， especially for patients with diabetic retinopathy.