Effects of BoFa on Expression of IL-6 and SOCS3 in Spinal Cord in CCI Rats

OBJECTIVE To explore the effect of BoFa for neuropathic pain in rats from the perspective of inflammatory reaction. METHODS The CCI model rats were intervened qualitatively and quantitatively by the massage simulation instrument. Observe the variation of rats' behavior though solar-thermal pain threshold resistance. Observe the variation of IL-6 and SOCS3 in spinal cord in rats through Immunohistochemical technique. RESULTS After seven days of surgery， the results of solar-thermal pain threshold resistance of the model group were significance changed than that of normal group(P<0.01)， the results of IL-6 and SOCS3 in spinal cord in rats were significantly increased than that of normal group(P<0.01). After twenty times of BoFa therapy， the results of solar-thermal pain threshold resistance of the BoFa group were significance changed than that of model group(P<0.05)， and near normal group level; the results of IL-6 in spinal cord in rats were significantly reduce than that of model group(P<0.01); the results of SOCS3 in spinal cord in rats were significantly increased than that of model group(P<0.01). CONCLUSION BoFa can improve the pain sense and temperature sense of CCI rats in a certain extent， and it also can inhibit the expression of pro-inflammatory factors in rats.