Lignans and Phenolic Compounds from Asparagus Gobicus

OBJECTIVE To study the chemical constituents of Asparagus Gobicus. METHODS Whole herb of Asparagus gobicus were extracted with 95% alcohol. Repeated silica gel column chromatography，Sephadex LH-20 chromatography， preparative HPLC and thin layer chromatography were applied for chemical constituents isolation and purification. Chemical structures of the compounds were elucidated by physical properties and spectra analysis such as NMR and ESI-MS. RESULTS Nine compounds were isolated from the extract of Asparagus gobicus. Six compounds were identified as lignans: (+)-pinoresinol（1）， (-)-syringaresinol（2）， (+)-syringaresinol-4'-O-β-D-glucopyranoside（3）， (-)-episyringaresinol（4）， (+)-nyasol（5）， (+)-4'-O-methylnyasol（6）. Three compounds were phenolic compounds: ferulic acid（7）， isoferulic acid（8）， caffeic acid（9）. CONCLUSION All compounds were isolated for the first time from this plant，and compounds 1~4 and 8 were obtained from the genus Asparagus for the first time.