Clinical Study of Modified Shaofu Zhuyu Decoction in Treating Adenomyosis Dysmenorrheal

OBJECTIVE To study the curative effects and action mechanism of using Shaofu Zhuyu decoction to treat adenomyosis dysmenorrhea. METHODS From June 2014 to June 2015 in our hospital 80 cases of patients with uterine adenomyosis dysmenorrhea were chosen and randomly divided into the observation group and the control group (40 cases in each group). The observation group had Shaofu Zhuyu decoction 5~7 d before dysmenorrhea， while the control group had Yueyue shu decoction， 1 bag/time. The two groups all had treatment of three menstrual cycles. Dysmenorrhea symptoms before and after treatment and the changes of TCM symptoms as well as the serum of CA125， TNF-α and IL-8 levels were recorded and compared， and ultrasound measurement was used to calculate the size of the uterus before and after the treatment. RESULTS In the two groups after treatment， dysmenorrhea scores and TCM symptoms all declined significantly (P<0.01)， but that of the observation group decreased more obviously (P<0.05). And after 3 courses of treatment in the observation group， the total effective rate was 95%， significantly higher than 67.5% in the control group; And TCM symptom in the observation group was 95% higher than 70% in the control group (P<0.05). Compared with the condition before treatment， uterine volume had no significantly changes differences after treatment (P>0.05). After treatment， uterine volume of the observation group compared with the control group had no significant differences (P>0.05). In the two groups after treatment CA125， TNF-α， IL-8 all declined significantly (P<0.05~0.01)， but that of the observation group decreased more obviously (P<0.05~0.01). During the treatment， heart， liver and kidney were all within the normal range， without obvious adverse reactions. CONCLUSION Using Shaofu Zhuyu Decoction to treat adenomyosis dysmenorrhea could significantly alleviate symptoms of patients with dysmenorrhea， relieving TCM symptoms. And its mechanism may be related to the lowering of the serum CA125， TNF-α， IL-8 levels.