Study on the Theory of "heterogeneous restriction" from the Material Base of Detoxicity Effect of the Compound Prescription of Chinese Herbal Medicine

LU Yan; XIE Tong; LI Huan; ZHOU Xue-ping

Volume 32 Issue 1

Jan. 2016

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Journal of Nanjing University of traditional Chinese Medicine > 2016 > 32(1): 97-100.

LU Yan, XIE Tong, LI Huan, ZHOU Xue-ping. Study on the Theory of "heterogeneous restriction" from the Material Base of Detoxicity Effect of the Compound Prescription of Chinese Herbal Medicine[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(1): 97-100.

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Study on the Theory of "heterogeneous restriction" from the Material Base of Detoxicity Effect of the Compound Prescription of Chinese Herbal Medicine

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Abstract

Abstract

The "Heterogeneous Restriction” theory comes from the clinical， which is the innovation of the traditional Chinese medicine theory， plays an important role in guiding the clinical application of toxic Chinese medicine. Under the guidance of "Heterogeneous Restriction” theory， in order to clarify the inherent mechanism of the compatibility of Chinese herbal medicine compound prescription， we must clarify the material base of detoxicity effect. Study on the mechanism of detoxicity effect on the basis of the compound prescription of Chinese herbal medicine， we should focus on three approaches: the toxic chemical constituents， the metabolism of toxic components， the correlation between toxic substances and effects. To explore in this field， we must .fully use the latest technology and research methods of modern science， and strengthen a multidisciplinary collaboration.
- heterogeneous restriction,
- Chinese herbal compound,
- compatibility detoxicity,
- material base

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[1]	李春庆，孙伟，邵家德，等．雷公藤减毒研究述评[J]．中国实验方剂学杂志，2011（10）：263-265．
[2]	Li CQ， Sun W， Shao JD， et al. Review research on attenuating toxicity of Chinese herb tripterygium wilfordii[J]. Chin J Exper Tradit Med Form， 2011(10): 263-265.
[3]	李桓，周学平，陆艳．雷公藤“异类相制”配伍减毒作用探讨[J]．中医杂志，2015（1）：10-13．
[4]	Li H， Zhou XP， Lu Y. Discussion on Detoxicity effect of Leigongteng in "diversity restriction”compatibility[J]. J Tradit Chin Med， 2015(1): 10-13.
[5]	张静，江莹，王芳，等．基于“异类相制”理论探讨雷公藤肝毒性配伍减毒的作用[J]．中草药，2014（18）：2711-2715．
[6]	Zhang J， Jiang Y， Wang F， et al. Detoxicity effect of hepatotoxicity of Tripterygium wilfordii by compatibility mechanism based on "diversity restriction" theory[J]. Chin Tradit Herb Drug， 2014(18): 2711-2715.
[7]	张新龙，郭立玮，周学平，等．清络通痹汤药效物质“组合筛选”库的制备[J]．中草药，2012（1）：60-64．
[8]	Zhang XL， Guo LW， Zhou XP， et al. Establishment of "combinatorial screening" library of efficacy substances for Qingluo Tongbi Decoction[J]. Chin Tradit Herb Drug， 2012(1): 60-64.
[9]	刘蒙竹，张新龙，潘林梅，等．清络通痹方中雷公藤配伍减毒的化学基础研究[J]．中国实验方剂学杂志，2014（7）：107-112．
[10]	Liu MZ， Zhang XL， Pan LM， et al. Chemical basis of tripterygium Qingluo wilfordii compatibility for attenuation in Tongbi decoction[J]. Chin J Exper Tradit Med Form， 2014(7): 107-112.
[11]	黄家卫，严云良，戴晓燕．配伍对桃核承气汤中苦杏仁苷代谢分解的影响研究[J]．中华中医药杂志，2012（6）：1688-1692．
[12]	Huang JW， Yan YL， Dai XY. Influence of compatibility difference on the content change of amarogentin in Taohe Chengqi Decoction[J]. China J Tradit Chin Med Pharm， 2012(6): 1688-1692.
[13]	周聪，周玲玲，柳璋璞，等．基于肝毒性的雷公藤复方配伍减毒作用及机制研究[J]．中药药理与临床，2013（5）：106-109．
[14]	Zhou C， Zhou LL， Liu ZP， et al. Study on attenuation effect of the compatibility of Compound Tripterygium wilfordii[J]. Pharmacol Clin Chin Mater Med， 2013(5): 106-109.
[15]	周昕欣．基于雷公藤毒性配伍组方对肾病雌性大鼠生殖系统影响的实验研究[D]．沈阳：辽宁中医药大学，2007．
[16]	Zhou XX. Experimental study on compatibility of Compound Tripterygium wilfordii on the reproductive system of female rat nephropathy[D]. Shenyang: Liaoning University of Chinese Medicine，2007.
[17]	王小娟．川楝子毒性及配伍减毒的代谢组学研究[D]．合肥：安徽医科大学，2011．
[18]	Wang XJ. The study on the metabolism of Melia toosendan Sieb's toxic and compatibility of drugs[D]. HeFei: Anhui University of Medicine，2011.
[19]	刘建群，王雪梅，刘一文，等. 基于影响药物代谢的中药配伍研究进展[J]. 中国实验方剂学杂志，2014，19:221-224.
[20]	Liu JQ， Wang XM， Liu YW， et al. Progress in compatibility of traditional Chinese medicine based on effect of drug metabolism[J].Chin J Exper Tradit Med Form， 2014(19):221-224.
[21]	陶长戈. 附子干姜组分配伍的胃肠吸收动力学研究[D].成都中医药大学，2011.
[22]	Tao CG. Gastrointestinal absorption kinetics of composition compatibilities from Radix Aconiti Lateralis and Rhizoma Zingiberis.[D]. Chengdu: Chengdu University of Chinese Medicine，2011.
[23]	刘建群，王雪梅，刘一文，等．基于影响药物代谢的中药配伍研究进展[J]．中国实验方剂学杂志，2014（19）：221-224．
[24]	Liu JQ， Wang XM， Liu YW， et al. Progress in compatibility of traditional Chinese medicine based on effect of drug metabolism[J]. Chin J Exper Tradit Med Form， 2014(19): 221-224.
[25]	陶长戈．附子干姜组分配伍的胃肠吸收动力学研究[D]．成都：成都中医药大学，2011．
[26]	Tao CG. Gastrointestinal absorption kinetics of composition compatibilities from Radix Aconiti lateralis and Rhizoma Zingiberis[D]. Chengdu: Chengdu University of Chinese Medicine，2011.
[27]	马婧伟．乌头类有毒中药炮制配伍减毒机制的体外模型研究[D]．长春：吉林大学，2014．
[28]	Ma JW. In vitro study an mechanism of attenuation in aconitum by processing and compatibility[D]. Changchun: Jilin University， 2014.
[29]	王加志．黄药子致肝毒性/配伍当归后减毒的亚细胞机制及毒性成分体外代谢研究[D]．哈尔滨：黑龙江中医药大学，2009．
[30]	Wang JZ. Dioscorea bulbiferal sends the liver toxicity to blend the angelica sinensis to reduce the poisonous subcellular fraction mechanism and the toxic ingredient in vitro metabolism research[D]. Haerbin: Heilongjiang University of Chinese Medicine， 2009.
[31]	陈长勋，徐姗珺．甘草、干姜与附子配伍减毒的物质基础与作用环节研究进展[J]．中药新药与临床药理，2006， 17（6）：472-476．
[32]	Chen CX， Xu SJ. Progress and research on the material basis and attenuated link among Licorice， ginger and Aconite[J]. Tradit Chin Drug Res Clin Pharm， 2006， 17(6): 472-476.
[33]	李彦文，李志勇，刘会永，等．中药配伍减毒研究的新思路[J]．中国实验方剂学杂志，2012（20）：321-324．
[34]	Li YW， Li ZY， Liu HY， et al. New thought of traditional Chinese medicine in detoxification by compatibility[J]. Chin J Exper Tradit Med Form， 2012(20): 321-324.
[35]	冯哲，周学平．复方配伍效应物质基础研究路径的探讨[J]．中华中医药杂志，2013（6）：1835-1838．
[36]	Feng Z， Zhou XP. Discussion of the research approach for the material foundation of the compatibility effect of traditional Chinese herbal formula[J]. China J Tradit Chin Med Pharm， 2013(6): 1835-1838.
[37]	郭浩，黎巍威，王小莹，等. 方剂配伍减毒的现代研究进展[J]. 中国中药杂志， 2012，01:120-123.
[38]	Guo H， Li WW， Wang XY， et al. Advance of research on toxic of traditional Chinese attenuation by compatibility medicine prescriptions[J]. China J Chin Mater Med， 2012(1):120-123.
[39]	赵佳伟，何家乐，马增春，等．参附配伍减毒作用的尿液代谢组学研究[J]．中药药理与临床，2015（1）：1-5．
[40]	Zhao JW， He JL， Ma ZC， et al. Urine metabolomics studies of Shenfu attenuated compatility[J]. Pharm Clin Chin Mater Med， 2015(1): 1-5.
[41]	李俊健．基于NMR的代谢组学对甘遂甘草配伍减毒机制的研究[D]．广州：广东药学院，2014．
[42]	Li JJ. NMR-based Metabonomics Study of the Attenuated of Kansui and Licorice Compatibility[D]. Guangzhou: Guangdong College of Pharmacy， 2014.
[43]	梁琦，谢鸣，倪诚，等. 广防己配伍黄芪肾毒性的代谢组学研究[J]. 浙江中医药大学学报， 2010(1):42-43，45.
[44]	Liang Q， Xie M， Ni C， et al. Nephrotoxicity study of Aristolochia Fangchi and it' s compatible with Astragali Radix in rats by metabonomics[J].J Zhejiang Univ Chin Med， 2010(1):42-43，45.
[45]	周学平，周玲玲，王旭．基于“异类相制”理论探讨中药复方的配伍减毒作用[J]．中医杂志，2013（4）：271-273．
[46]	Zhou XP， Zhou LL， Wang X. Study on the compatibility of Chinese herbal medicine compound by The "Heterogeneous Restriction" theory[J]. J Tradit Chin Med， 2013(4): 271-273.

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Study on the Theory of "heterogeneous restriction" from the Material Base of Detoxicity Effect of the Compound Prescription of Chinese Herbal Medicine

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