XUShi-Jun, XIONGMin, HUYong, ZHANGYin-Jie, JUShao-hua, DAIYong, WANGFei, ZHANGTing-mo. Effect of Ganduqing Granule on Allergy[J]. Journal of Nanjing University of traditional Chinese Medicine, 2013, 29(3): 259-261.
Citation: XUShi-Jun, XIONGMin, HUYong, ZHANGYin-Jie, JUShao-hua, DAIYong, WANGFei, ZHANGTing-mo. Effect of Ganduqing Granule on Allergy[J]. Journal of Nanjing University of traditional Chinese Medicine, 2013, 29(3): 259-261.

Effect of Ganduqing Granule on Allergy

More Information
  • Received Date: March 07, 2013
  • Revised Date: April 20, 2013
  • OBJECTIVE To analyze the anti-allergy effect of Ganduqing granule and to provide experimental basis for its clinic application.METHODS The influence of Ganduqing granule on rat's skull Periost mast cells degranulation was observed and Passive skin allergy model in rats was prepared to observe the effect of Ganduqing granule on allergy.RESULTS In the rat's skull Periost mast cells degranulation rate, compared with the model group, the high-,medium-and low-dose Ganduqing granule groups were significantly decreased(P<0.05).The data of rats skin optical density in antisera injection site wew analyzed by one-way ANOVA, which showed that there was significant difference among groups in 1∶2 antisera injection site (P<0.05), but there was no significant difference among groups in 1∶1 antisera injection site. In the PCA 1∶2 antisera injection site, compared with the model group, the optical density in the high-,medium-and low-dose Ganduqing granule groups were significantly decreased(P<0.05).CONCLUSION Ganduqing granule has a significant effect on allergy.
  • [1]
    熊敏,张荫杰,徐世军,等.感毒清颗粒抗炎镇痛作用研究[J].中药药理与临床,2012, 28(3):89-92.
    [2]
    Xiong M, Zhang YJ, Xu SJ, et al.Research on Ganduqing granule anti-inflammatory and analgesia effects[J]. Pharmacol Clin Chin Mater Med, 2012, 28(3): 89-92.
    [3]
    Choi YH,Yan GH.Silibinin attenuates mast cell-mediated anaphylaxis-like reactions[J].Biol Pharm Bull,2009,32(5):868-875.
    [4]
    钟正贤,陈学芬,周桂芬,等.水半夏提取物的抗炎抗过敏作用研究[J].中药药理与临床,2003, 19(2):25-27.
    [5]
    Zhong ZX, Chen XF, Zhou GF, et al.Research on pinellia water extract anti-inflammatory and anti-allergy effects[J]. Pharmacol Clin Chin Mater Med, 2003, 19(2): 25-27.
    [6]
    KovarovaM, R ivera J. Amolecular understanding of mast cell activation and the promise of antiallergic the rapeutics[J]. Curr Med Chem, 2004, 11(15):2083-2091.

Catalog

    Article Metrics

    Article views PDF downloads Cited by()
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return