Research Progress on Sources， Structural Modification and New Dosage Forms of Ginkgolides

Ginkgolide is a kind of azlactone compound isolated from Ginkgo biloba leaves and roots. It acts as a potent platelet activating factor (PAF) antagonist and non-specific Glycine receptor (GlyR) and γ- Γ-Amino-Bu-Tyric acid (GABA) receptor antagonists are widely used in cardiovascular and cerebrovascular diseases. Since the discovery of PAF antagonistic activity of lactone components in Ginkgo biloba extract， many scientists have conducted extensive research on the structure-activity relationship， structural modification， and pharmacological effects of such compounds. As a natural drug， ginkgolides have the advantages of good curative effect and small side effects， and have a good development trend. The research and development of ginkgolides， ginkgolides and their preparations will bring better economic and social benefits. For the benefit of mankind. This article reviews the research and recent progress of ginkgolides， and reviews its development process and related research， with a view to bringing new thinking to the development of natural medicines.