Clinical Research on the Desheng Elixir Treating Sterility of Ovulation Disturbance Patients with Kidney Deficiency and Liver Depression Syndrome

OBJECTIVE To observe the clinical effect of Zhongyuan Men's proved recipe Desheng elixir on sterility of ovulation disturbance patients with kidney deficiency and liver stagnation syndrome. METHODS 120 cases of sterility of ovulation disturbance with kidney deficiency and liver depression syndrome were randomly divided into three groups: traditional Chinese medicine group (using Desheng elixir)， combination group (using Desheng elixir + clomiphene)， western medicine group (using clomiphene only). After 12 weeks of treatment， the leading follicle diameter， endometrial thickness， cervical mucus (Insler) score， ovulation rate， pregnancy rate， serum estradiol (E₂) and progesterone (P) levels in the three groups were observed. RESULTS After treatment， the leading follicle diameter in the three groups increased significantly compared with that before treatment (P<0.05，P<0.01)， among which the combination group and the western medicine group increased more significantly (P<0.01). The TCM syndrome scores of the three groups decreased significantly (P<0.01)， among which the combination group and the Chinese medicine group decreased more significantly (P<0.01). The endometrial thickness and Insle score in the Chinese medicine group and the combination group increased (P<0.01)， more significantly than those in the western medicine group (P<0.05，P<0.01). Serum E₂ level increased in the three groups on the day of ovulation (P<0.01)， among which the combination group and the Chinese medicine group increased more significantly (P<0.05).Serum P level in the luteal phase increased significantly in the Chinese medicine group and the combination group (P<0.01)， better than that in the western medicine group (P<0.05，P<0.01). From the perspective of ovulatory rate， the combination group and the western medicine group increased more than that in the Chinese medicine group (P<0.05，P<0.01). As to the pregnancy rate， the combination group was higher than the other two (P<0.05， P<0.01) and the Chinese medicine group was higher than the western medicine group (P<0.05). CONCLUSION Desheng elixir can improve the clinical symptoms of sterility of ovulation disturbance patients with kidney deficiency and liver depression syndrome， reduce the adverse effect of clomiphene alone on inhibiting endometrium， and improve the clinical ovulation and pregnancy rate.