Clinical Curative Effects Analysis of Self-made Yishen Jianpi Huayu Formula in the Treatment of Syndrome of Spleen and Kidney Yang Deficiency of Postmenopausal Osteoporosis

OBJECTIVE To study the Clinical curative effect of self-made Yishen Jianpi Huayu Formula in the treatment of syndrome of spleen and kidney yang deficiency of postmenopausal osteoporosis. METHODS From January 2016 to January 2017， 120 postmenopausal osteoporosis patients included in our hospital were selected and randomly divided into the observation group and the control group by random number， 60 cases in each group. Both groups were given calcium carbonate D3 tablets. On the basis of this， the control group was given xianlinggubao capsules， and the observation group was given self-made Yishen Jianpi Huayu Formula. Both groups were treated for three months. RESULTS After treatment， the total clinical symptoms cores of lumbar and back pain， soreness and weakness of waist and knees， increasing of night urine， aversion to cold and cold limbs and lassitude in both groups were decreased significantly(P<0.01)， but the observation group decreased more significantly (P<0.01). After treatment， the total effective rate in the observation group was 93.33%， which was significantly higher than that in the control group (80.00%， P<0.01). The bone mineral density of lumbar spine， L2~L4， femoral neck， greater trochanter of femur and Ward's pyramidal bone were significantly increased compared with pretreatment (P<0.01)， but the observation group increased more significantly (P<0.01). Bone specific alkaline phosphatase (B-ALP) and tartrate resistant acid phosphatase(TRACP) in both group were decreased significantly (P<0.01) compared with pretreatment， but the observation group decreased more significantly (P<0.01). Estradiol (E₂)， insulin growth factor (IGF-1) in both group were increased significantly compared with pretreatment (P<0.01)， and the observation group increased more significantly (P<0.01). The adverse events occurrence rates in both groups had no significant difference (P＞0.05). CONCLUSION Self-made Yishen Jianpi Huayu formula can significantly improve the clinical symptoms of postmenopausal osteoporosis， and improve patients' bone metabolism and bone mineral density at the same time. Its action mechanism may be associated with increased estrogen and IGF-1 levels.