Therapeutical Effects of Aspirin and XueShuanTong on Patients with the Drug Resistance of ITGB3 Genes Polymorphism

OBJECTIVE To investigate the relationship between ITGB3 gene polymorphism and therapeutic effects of XueShuanTong and aspirin on cerebral infarction with anti-platelet. METHODS 192 patients with cerebral infarction were collected and randomly divided into 4 groups. According to patients general information， biomedical index and thromboelastogram， DNA genome were extracted from venous blood and detected by using Snapshot method， and then analyzed the situations of anti-platelet and compared the results of 4 groups. RESULTS Generally， the inhibitory ratio of platelet increased obviously after the patients were treated with drugs. Compared with aspirin group， the inhibitory ratio of platelet increased obviously in patients with ITGB3 genes(AA， AG， GG) treated by XueShuanTong pharmaceutics， and no significant difference appeared among these 3 groups. CONCLUSION XueShuanTong pharmaceutics can inhibit platelet aggregation， which will prevent the drug resistance in patients with mutant ITGB3 genes(AA and GG).