CAOWei-ping, SHIWei, LIXia, MAQing, WUMei-ling, WANGDong-mei. Study on the Action Mechanism of Combined Jiaweishoutai Wan and Progesterone in Regulating NKG2D and NKG2A Expression for Treating URSA of Kidney Deficiency Type[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(5): 488-492.
Citation: CAOWei-ping, SHIWei, LIXia, MAQing, WUMei-ling, WANGDong-mei. Study on the Action Mechanism of Combined Jiaweishoutai Wan and Progesterone in Regulating NKG2D and NKG2A Expression for Treating URSA of Kidney Deficiency Type[J]. Journal of Nanjing University of traditional Chinese Medicine, 2017, 33(5): 488-492.

Study on the Action Mechanism of Combined Jiaweishoutai Wan and Progesterone in Regulating NKG2D and NKG2A Expression for Treating URSA of Kidney Deficiency Type

  • OBJECTIVE To investigate NK cells activity changes in the occurrence of URSA, and explain the action mechanism of combined Gushen Antai experienced formula "Jiaweishoutai Wan" and progesterone in the treatment of URSA by regulating expression changes of NK cell receptor to induce immune tolerance. METHODS Twenty patients with kidney deficiency type URSA successfully treated by combined Jiaweishoutai Wan and progesterone were chosen. And URSA pregnancy loss patients and HEP patients at the same period were selected, 15 cases in each group. The expression of NKG2D and NKG2A in peripheral blood were detected by flow cytometry. The levels of E2, P and β-HCG in the URSA pregnancy group and HEP group were compared after treatment. RESULTS In URSA pregnancy loss group, the expression of NKG2D of NK cells was higher and NKG2A was lower, the differences were statistically different compared with HEP group (P<0.01). NKG2D expression level of pNK cells in URSA pregnancy group was significantly lower than that of pretreatment, and the difference was statistically different compared with URSA pregnancy loss group (P<0.01); and the NKG2A expression level was obviously higher than that of pretreatment (P<0.01), the difference was not statistically significant compared with HEP group, and the difference was statistically different compared with URSA pregnancy loss group (P<0.01). After treating with combined Jiaweishoutai Wan and progesterone, the blood serum E2, P and β-HCG levels in URSA pregnancy group were all not significantly different with that in the HEP group (P>0.05). CONCLUSION The expression of NK cells receptors including NKG2D and NKG2A is involving in the occurrence of URSA. The combined Jiaweishoutai Wan and progesterone can treat URSA by down regulating the NKG2D expression levels of URSA patients and up regulating NKG2A expression levels to induce maternal fetal immune tolerance. Gushen Antai method is an effective treating method for URSA of kidney deficiency type. Jiaweishoutai Wan is an effective formula for treating URSA of kidney deficiency type.
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