Relationship Between TCM Syndrome Types and Clinical Biochemical Indexes in Type 2 Diabetes Mellitus

OBJECTIVE To study the relationship between TCM syndrome types and clinical biochemical indexes in type 2 diabetes mellitus， and to an objective basis for TCM syndrome differentiation of type 2 diabetes mellitus. METHODS 120 type 2 diabetes mellitus patients corresponding to the study criteria were collected. Syndrome differentiation was made for these patients according to yin deficiency and heat excess， spleen deficiency， phlegm accumulation， deficiency of both Qi and Yin and qi deficiency and blood stasis. At the same time， 40 healthy subjects were matched as controls. The relationships between different types and age， body mass index (BMI)， glucose metabolism， lipid metabolism， hypersensitivity C reactive protein (hs-CRP)， insulin resistance indexes (HOMA-IR) and serum insulin (FINS) were analyzed. RESULTS ①Compared with the normal control group， BMI in the yin deficiency and heat excess group decreased significantly (P<0.01)， BMI in the spleen deficiency and phlegm accumulation group increased significantly (P<0.01). ②Compared with the normal control group， all indexes of TC， TG and LDL in the diabetes mellitus group increased (P<0.05)， HDL index decreased (P<0.05). ③All FPG， HOMA-IR， HbA1c and hs-CRP levels in the diabetes mellitus group increased compared with the normal control group (P<0.05～0.01). Apart for the yin deficiency and heat excess group， FINS indexes in the rest three group had significant differences compared with the normal control group (P<0.05). CONCLUSION There are correlations between various TCM syndromes of type 2 diabetes mellitus and lipid metabolism， glucose metabolism， body mass index and insulin resistance index. The study of the relationship between them will contribute to the objectification of TCM syndrome differentiation in diabetes mellitus.