Study on Different Compatibility of Shuangshen Pingfei Decoction Influence on Decocting Rate of Mangiferin in Anemarrhena asphodeloides

OBJECTIVE To explore the influence of different compatibility of Shuangshen Pingfei decoction on the decocting rate of mangiferin in Anemarrhena asphodeloides， and ingredients to research influence on the mechanism of the solution rate. METHODS To disassemble formulas on the basis of the prescription of traditional Chinese medicine containing categories of ingredients. With decocting rate of mangiferin in Anemarrhena asphodeloides Bge as indexes， analyse different compatibility influence on mangiferin decocting rate. Based on these results of disassembled formulas， the representative alkaloid 1-Deoxynojirimycinand amino acid in different compatibility are used to research the influence of compositions of white mulberry on the decocting rate of mangiferin in Anemarrhena asphodeloides Bge and discuss the influence of the decocting rate mechanism with Anion and cation exchange resin processing of samples. RESULTS Research findings shows that the decocting rates of mangiferin in Anemarrhena asphodeloides Bge decoction， prescription combined decoction， Anemarrhena asphodeloides Bge-saponins from Chinese herbal compound， Anemarrhena asphodeloides Bge-phenolic acid from Chinese herbal compound are 97.33%， 47.03%， 94.08%， 57.53%， 34.31%， respectively; Further study shows that Morus alba L. combined with Anemarrhena asphodeloides Bge have the most obvious effect on extraction yield of mangiferin. Anemarrhena asphodeloides Bge decoting with total alkaloids of Morus alba L， DNJ， glycine， β-alanine， respectively. The decocting rate of mangiferin in each group was 16.64%， 28.13%， 40.75% and 48.56%， respectively. CONCLUSION Our results suggest that the decocting rates of mangiferin are mainly influenced by Morus alba L. We also conjectured that alkaloids and amino acids of Morus alba L. form complexes with mangiferin.