ZHANG Qing-mei, SHANG Qing, MA Cai-yun, LIN Hai-feng, ZHANG Yu. Influence of Ziyin Shugan Xiehuo Formula on Secondary Sex Characteristics and Growth of Girls with Idiopathic Central Precocious Puberty[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(6): 524-527.
Citation: ZHANG Qing-mei, SHANG Qing, MA Cai-yun, LIN Hai-feng, ZHANG Yu. Influence of Ziyin Shugan Xiehuo Formula on Secondary Sex Characteristics and Growth of Girls with Idiopathic Central Precocious Puberty[J]. Journal of Nanjing University of traditional Chinese Medicine, 2016, 32(6): 524-527.

Influence of Ziyin Shugan Xiehuo Formula on Secondary Sex Characteristics and Growth of Girls with Idiopathic Central Precocious Puberty

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  • OBJECTIVE To study the influence of Ziyin Shugan Xiehuo Formula on secondary sex characteristics and growth of girls with idiopathic central precocious puberty. METHODS 74 cases of idiopathic central type precocious puberty belonging to fire excess from yin deficiency type were selected from June, 2013 to June, 2015 in our hospital and randomly divided into the control group and the observation group, with 37 cases in each group. Patients in the observation group were given Ziyin Shugan Xiehuo Formula for nourishing kidney, soothing liver and purging fire, while those in the observation group was treated with Da Buyin Pill. After 6 months of treatment, TCM symptom improvements and changes of serum LH, FSH, E2, bone age, ovary and uterus volume before and after treatment were observed and compared. The clinical curative effects and adverse reaction of the two groups were evaluated. RESULTS The total effective rate of the observation group was 94.6%, which was significantly higher than 73.0% of the control group(P<0.05). During the treatment, indexes of the two groups including routine urine test, blood urine test, heart, liver and kidney were all within the normal ranges with no obvious adverse being detected. TCM symptom scores of both groups were significantly decreased after treatment(P<0.01), but the observation group decreased more obviously(P<0.01). Advanced bone ages were notably improved in both groups after treatment(P<0.05~0.01), with the observation group being more superior to the control group(P<0.01). FSH, LH and E2 levels of two groups after treatment were significantly improved(P<0.05), but the observation group improved more significantly(P<0.05). Both ovarian and uterine volume of the two groups were significantly reduced after treatment(P<0.05), but the observation group reduced more obviously(P<0.05). CONCLUSION Ziyin Shugan Xiehuo Formula can obviously decrease sex hormone levels of girls with idiopathic central precocious puberty due to fire excess from yin deficiency, control and improve the occurrence of secondary sex characteristics of the girls, and inhibit the rapid growth of bone age with high safety.
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