Research progress on the Metabolomics in the Traditional Chinese medicine (TCM) and its compound

Nicholson JK，Lindon JC，HolmesE. Metabonomics: understanding themetabolic responses of living systems to pathophysiological stimulivia multivariate statistical analysis of biological NMR spectroscopic data[J]. Xenobiotica，1999(29):1181-1189.

Taylor J， King RD， Altmann T， et al. Application of metabolomics to plant genotype discrimination using statistics and machine learning[J]. Bioinformatics， 2002，18(Suppl2): 241-248.

Dong H， Zhang AH， Sun H， et al. Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods[J]. Molecular Bio Systems，2012，8:1206-1221

Mlawule RM， Karl R， Marjan DM， et al. Microbial metabolomics: past， present and future methodologies[J]. Biotechnology Letters，2007，29（1）:1-16

Qiu YP， Chen MJ， Su MM. Metabolic profiling reveals therapeutic effects of Herba Cistanchesin ananimal model of hydrocortisone-induced “kidney-deficiencysyndrome”[J]. Chinese Med，2008，(10):1186-1193.

Tang HR，Wang YL. Metabonomics: a revolution in progress[J] .Prog Biochem Biophys，2006，33(5):401.

杨萍，贾钰华，李杰. 代谢组学技术及其在中医药领域中的应用[J].辽宁中医杂志，2009，36（1）:32-35.

Yang P， Jia YH， Li J.Metabonomics and its Application to Traditional Chinese Medcine[J].Liaoning J Tradit Chin Med， 2009，36(1):32-35.

王广基，查伟斌，郝海平，等. 代谢组学技术在中医药关键科学问题研究中的应用前景分析[J].中国天然药物，2008，6（2）:89-97.

Wang GJ， Zha WB， Hao WP， et al. Application Analysis of the Metabonomics in Key Scientific Problems of Traditional Chinese Medicine [J]. Chin J Nat Med，2008，6(2):89-97.

King RD，Whelan KE，Jones FM，et al.Functional genomic hypothesis generation and experimentation by a robot scientist[J].Nature，2004， 427(2):247.

Lu XM，Xiong ZL，Li JJ， et al. Metabonomic study on 'Kidney-Yang Deficiency syndrome' and interventioneffects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry[J]. Talanta，2011(83):700-708.

Jiang ZJ， Liu F， Ong ES， et al. Metabolic profile associated withglucoseand cholesterol Lowering Fects Of berberine in Sprague-Dawley rats[J]. Metabolomics，2012(8):1052-1068.

Tong X，Sun H，Yan GL， et al. Evaluation Study on Urine Metabolomics in Yinhuang Rat Model Induced by Triplet Factors of Rhubarb， Ethanol， and α-Nephthylisothiolyanate[J].Chin J Integr Med，2011(5):369-375.

Luo HG，Chen JX，Zhang Q， et al. Comparative Study on Effects of Xiaoyao Powder and Its Modifi ed Prescription on Plasma Metabolomics of Rats with Chronic Immobilization Stress[J].Chin J Integr Med， 2012(10):1092-1097.

Chen HJ，Shen YC， Lin CY. Metabolomics study of Buyang Huanwu Tang Decoctionin ischemic stroke mice by¹HNMR[J]. Metabolomics，2012(8):974-984.

Keiko L， Masahiro S， Tomoyoshi S， et al. Profiling of the charged metabolites of traditional herbalmedicines using capillary electrophoresis time-of-flight mass spectrometry[J]. Metabolomics，2011:290-299.

Wang SX，Luo K， Liang J. Metabolomics study on the synergistic interaction between Salviamiltiorrhiza and Lignum dalbergiae odoriferae used as 'Jun-Shi' herbs in a Smiltiorrhiza recipe[J]. Med Chem Res，2011(20):16-22.

Guo XX，Yan N， Ming M， et al. Application of ultra–performance LC-TOF-MS metabolite profiling techniques to the analysis of medicinal Panax herbs[J]. Metabolomics，2008(4):248-260.

Ha YW， Na YC， Ha IJ， et al. Liquid chromatography/mass spectrometry-based structural analysis of new platycoside metabolites transformed by human intestinal bacteria[J]. J Pharmaceut Biomed Anal，2010(51):202-209.

Aravindaram K， Yang NS. Metabolomics in Medicinal Plant Research[M]. New York: Biotechnology for Medicinal Plants，2013:275-294.

Chen T，Mei N. Genotoxicity of pyrrolizidine alkaloids[J]. J Appl Toxicol， 2010（30）：183-196.

Xiong AZ，Yang L， Ji LL. UPLC-MS based metabolomicstudy on Senecio scandens and S. vulgaris: an approch for the differentiation of two Senecioherbs with similar morphology but different toxicity[J]. Metabolomics，2012(8):614-623.