Study on Phospholipid Complex Improving Oral Danshensu Bioavailability

OBJECTIVE To explore pharmacokinetic features of Danshensu phospholipid complex（DPLC） in rats and compare with Danshensu APIs. METHODS Danshensu and DPLC (containing the same amount of Danshensu) were taken in intragastric administration.The concentration of Danshensu in plasma was detected in LC-MS/MS method while pharmacokinetic parameters were calculated with DAS 2.1.1 software. RESULTS In Danshensu group， C _max was（1.28±0.13）×10³ ng/mL，T _max was (51±8.22) min，AUC _0-t was （2.05±0.24）×10⁵  ng/(mL·min)；in DPLC group， C _max was （1.88±0.07）×10³ ng/mL，T _maxwas (90±18.37) min，AUC _0-t was （3.07±0.50）×10⁵ ng/(mL·min). CONCLUSION Phospholipid complex can increase oral Danshensu bioavailability.