Therapeutic Effects of Danggui Buxue Decoction and its Decomposition on Rats with Immunological Liver Injury

OBJECTIVE To observe effects of Danggui Buxue Decoction and the composition on liver function and liver fibrosis in rats with immunological liver injury. METHODS The immunological liver injury models were established with intraperitoneal administration of pig serum， whose alanine aminotransferase (ALT)， aspartate aminotransferase(AST)， superoxide dismutase(SOD)， lipid peroxide malondialdehyde (MDA)， Hyaluronic acid (HA)， IV collagen and III procollagen were detected. RESULTS The group with ratio of Astragalus root to Chinese angelica 5:1 significantly decreased AST and ALT levels; Astragalus root group， Chinese angelica group and groups with different ratios of Astragalus root to Chinese angelica increased SOD levels and decreased MDA content; Astragalus root group obviously reduced HA and type-IV collagen; Danggui Buxue Decoction group with the ratio 5:1 significantly reduced type-III procollagen levels， superior to that in group with ratio10:1. CONCLUSION Danggui Buxue Decoction makes a certain effect on rats with immunological liver injury， whose mechanism may be related to reduction and inhibition of lipid peroxidation and anti-free radical damage.