Volume 30 Issue 2
Mar.  2014
Turn off MathJax
Article Contents
Abstract
References
SUNLi-xia, FANGNan-yuan, ZHOULing-Ling, LIUZhang-pu. Therapeutic Effects of Danggui Buxue Decoction and its Decomposition on Rats with Immunological Liver Injury[J]. Journal of Nanjing University of traditional Chinese Medicine, 2014, 30(2): 150-152.
Citation: SUNLi-xia, FANGNan-yuan, ZHOULing-Ling, LIUZhang-pu. Therapeutic Effects of Danggui Buxue Decoction and its Decomposition on Rats with Immunological Liver Injury[J]. Journal of Nanjing University of traditional Chinese Medicine, 2014, 30(2): 150-152.
shu

Therapeutic Effects of Danggui Buxue Decoction and its Decomposition on Rats with Immunological Liver Injury

  • 1.

    The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China

  • 2.

    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

More Information
  • Received Date: November 07, 2013
  • Revised Date: December 18, 2013
    Graphical Abstract
    • Abstract
  • OBJECTIVE To observe effects of Danggui Buxue Decoction and the composition on liver function and liver fibrosis in rats with immunological liver injury. METHODS The immunological liver injury models were established with intraperitoneal administration of pig serum， whose alanine aminotransferase (ALT)， aspartate aminotransferase(AST)， superoxide dismutase(SOD)， lipid peroxide malondialdehyde (MDA)， Hyaluronic acid (HA)， IV collagen and III procollagen were detected. RESULTS The group with ratio of Astragalus root to Chinese angelica 5:1 significantly decreased AST and ALT levels; Astragalus root group， Chinese angelica group and groups with different ratios of Astragalus root to Chinese angelica increased SOD levels and decreased MDA content; Astragalus root group obviously reduced HA and type-IV collagen; Danggui Buxue Decoction group with the ratio 5:1 significantly reduced type-III procollagen levels， superior to that in group with ratio10:1. CONCLUSION Danggui Buxue Decoction makes a certain effect on rats with immunological liver injury， whose mechanism may be related to reduction and inhibition of lipid peroxidation and anti-free radical damage.
    • FullText(HTML)
    • References (19)
  • [1]
    陶艳艳，陈园，陈高峰，等．当归补血汤不同配比组方的抗肝纤维化作用[J]．上海中医药大学学报，2008， 22（1）：40-44．
    [2]
    Tao YY， Chen Y， Chen GF， et al. Anti-hepatic Fibrosis Effect of "Danggui Buxue Decoction" with Different Proportions of Radix Astraga and Angelica Sinensis in Rats[J]. Acta Univ Tradit Med Sin Pharmacol Shanghai， 2008， 22(1): 40-44.
    [3]
    袁国红，顾立刚．当归补血汤对血细胞及相关免疫因子的作用[J]．中国组织工程研究与临床康复，2007， 11（28）：5606-5609．
    [4]
    Yuan GG， Gu LG. Effect of danggui buxue tang on blood cells and some relative active factors[J].Chin J Tis Engineer Res， 2007， 11(28): 5606-5609.
    [5]
    Islam MN， Choi RJ， Jin SE， et al. Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva[J]. J Ethnopharmacol， 2012， 144(1): 175-181.
    [6]
    Han C GJ， pairs activity of traditional Chinese herb anti-inflammatory. Angelica sinensis and Sophora flavescens[J]. Inflammation， 2012， 35(3): 913-919.
    [7]
    Lee HJ， Choi TW， Kim HJ， et al. Anti-Inflammatory activity of angelica keiskei through suppression of mitogen-activated protein kinases and nuclear factor-kappaB activation pathways[J]. J Med Food， 2010， 13(3): 691-699.
    [8]
    刘雅，张海港，张翼冠，等．当归补血汤对气虚血瘀大鼠免疫功能及相关基因的调控[J]．中药药理与临床，2009， 25（5）：10-13．
    [9]
    Liu Y， Zhang HG， Zhang YG， et al.The regulation effects of Danggui Buxue Decoction on immune function of rats with qi deficiency and blood stasis and related genes[J]. Pharmocol Clin Chin Mater Med， 2009， 25(5): 10-13.
    [10]
    苗明三，方晓艳．当归补血汤粗多糖对免疫抑制小鼠免疫功能的影响[J]．中药药理与临床，2003， 19（6）：8-9．
    [11]
    Miao MS， Fang XY. Effects of Dangguibuxuetang polysaccharide on immunological functions of immunosuppressional model mice[J]. Pharmocol Clin Chin Mater Med， 2003， 19(6): 8-9.
    [12]
    Chang MS， Kim do R， Ko EB， et al. Treatment with Astragali radix and Angelicae radix enhances erythropoietin gene expression in the cyclophosphamide-induced anemic rat[J]. J Med Food， 2009， 12(3): 637-642.
    [13]
    Hui MK， Wu WK， Shin VY， et al. Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice[J]. Int J Med Sci， 2006， 3(1): 1-6.
    [14]
    陈奇．中药药理研究方法学[M]．北京：人民卫生出版社，1993：851-853．
    [15]
    Chen Q．The research on traditional Chinese medicine pharmacology's methodology[M]. Beijing: people's medical publishing house， 1993:851-853.
    [16]
    Gossard AA， Lindor KD. Autoimmune hepatitis: a review[J]. J Gastroenterol， 2012， 47(5): 498-503.
    [17]
    Achenza MI， Meda F， Brunetta E， et al. Serum autoantibodies for the diagnosis and management of autoimmune liver diseases[J]. Expert Rev Gastroenterol Hepatol， 2012， 6(6): 717-729.
    [18]
    肖柳英，潘竞锵，饶卫农，等．补阳还五汤对小鼠免疫性肝炎及急性肝损伤的保护作用研究[J]．中医研究，2005， 18（6）：13-14．
    [19]
    Xiao LY， Pan JQ， Rao WN， et al. Protection of the wuyang huanwu decoction from immune hepatitis and acute liver trauma in mice[J]. Tradit Chin Med Res， 2005， 18(6): 13-14.
    • Related Articles

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (928) PDF downloads (1061) Cited by()
    Related

    Copyright © Journal of Nanjing University of traditional Chinese Medicine

    Sponsored by：Nanjing University of traditional Chinese MedicineAddress：No.138 xianlin Avenue, Qixia District, Nanjing cityChina Pos：210023

    Tel：025-85811935Email：xb@njucm.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return