Clinical Study of Xuzao Gengping Powder Treating Female Climactic Primary Hypertension

OBJECTIVE To observe clinical efficacy of Xuzao Gengping Powder Treating female climacteric primary hypertension by ambulatory blood pressure. METHODS Selected 92 patients treated in Hypertension Department of Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital from March 2008 to October 2009. 92 cases of climacteric hypertension with internal dryness due to yin deficiency were randomly divided into 48-case treatment group and 44-case control group. 24-hour ambulatory blood pressure monitoring (ABPM) was performed before and after treatment and effect of treatment on blood pressure variability and rhythm were analyzed. RESULTS ①Compared with control group， only 24h diastolic blood pressure variation(24h DSD/DBPV) in treatment group had no statistical significance(P>0.05). 24h systolic blood pressure variation(24h SSD/SBPV)， day systolic blood pressure variation(d SSD/SBPV)， day diastolic blood pressure variation(d DSD/DBPV)， night systolic blood pressure variation(n SSD/SBPV)， night diastolic blood pressure variation(n DSD/DBPV) all had statistical significance(P<0.05). ②Compared with control group， average blood pressure expect 24h average diastolic blood pressure(24h DBP) and day average diastolic blood pressure(d DBP) in treatment group had no statistical significance(P>0.05). 24h average systolic blood pressure(24h SBP)， day average systolic blood pressure(d SBP)， night average diastolic blood pressure(n DBP)， night average systolic blood pressure(n SBP) all decreased， had statistical significance(P<0.05). As to blood pressure therapeutic effect， the total effective rate of treatment group was higher than that of control group and had statistical significance(P<0.05). Night blood pressure decrease rate ascended obviously and had statistical significance(P<0.05). CONCLUSION Xuzao Gengping Powder treating climacteric hypertension can adjust blood pressure rhyme， decrease blood variability and reduce level of systolic blood pressure obviously. Particularly， it has significant effect on night blood pressure variation.