Rat In Vivo Study on Absorption of Active Components of Tongsaimai Micro-pellet

OBJECTIVE To examine the absorption dynamics of the active components of Tongsaimai Micro-pellet at different portions of the intestine and the absorption differences between micro-pellet and the standard drug and evaluate the rationality of this preparation. METHOD In vivo experiment was used to observe the absorption in rat small intestine.RESULT The active components of Tongsaimai Micro - pellet were well absorbed at different portions of the intestine, with no specific absorption locations. Different concentrations of the solution did not affect the absorption of liquirtin, ferulaic acid and ammonium glycyrrhizinate, but affected the absorption of cinnamic acid. CONCLUSION The liquirtin, ammonium glycyrrhizinate and cinnamic acid in the standard drug are absorbed faster than those in the micro-pellet, but no marked differences were detected in the absorption of ferulaic acid, suggesting the enduring effect of micro-pellets.