Pharmacodynamic Study on Treatment of Functional Uterine Bleeding with Jingxueshu Granule

OBJECTIVE To carry out experimental verification on related functions of Jingxueshu Granule.METHOD Observations were made on the effect of Jingxueshu Granule on mice claw pain,the contents of aquadiol and corporin in the serum of rats,the excitability of the smooth muscle of mice uterus,the tail-cutting bleeding time of normal mice and the blood rheology of model rats.RESULT Jingxueshu Granule at low,medium and high dosages could inhibit mice claw pain caused by hot plate,with marked difference as compared with the model group(P<0.05,P<0.01).Jingxueshu Granule at low,medium and high dosages could increase the content of aquadiol,with marked difference as compared with the model group(P<0.01).Jingxueshu Granule could increase the content of serum corporin,but with no marked difference as compared with the model group.Jingxueshu Granule at low, medium and high dosages could increase the contraction of uterus smooth muscle and can be used in combination with oxytocin,with marked difference as compared with the blank control group(P<0.01,P<(0.05)).Jingxueshu Granule at low,medium and high dosages could reduce whole blood viscosity and plasma specific viscosity,with marked difference as compared with the model group(P<0.01,P<0.05).CONCLUSION Jingxueshu Granule has analgesic and tranquilizing effect and can promote uterine smooth muscle contraction,arrest blood,activating blood circulation and removing blood stasis.