Multi-Target Intervention Mechanism and Clinical Application of Traditional Chinese Medicine in CVB3-Induced Viral Myocarditis

Viral myocarditis (VMC) is a type of myocarditis caused by Coxsackievirus B3 (CVB3) infection. Its pathogenesis is complex that includes direct viral action, host immune and inflammatory response, myocardial structure and function remodeling. The therapeutic effect of single target drugs is limited, while traditional Chinese medicine not only has antiviral effects, but also demonstrates systematic advantages in intervening in VMC due to its "multi-component, multi-target, and multi-pathway" characteristics. This article reviews the pathogenic mechanisms of CVB3-induced VMC, clarifies the interaction between CVB3 and host cells, and explores the intervention mechanisms and developments of traditional Chinese medicine interventions for CVB3-induced VMC. At the same time, the prospects of traditional Chinese medicine treatment for CVB3-induced VMC in this study suggest that future research should strengthen the analysis of multi-target synergistic mechanisms based on traditional Chinese medicine formulas, combine artificial intelligence, genomics, and gene editing technologies to predict drug-target interaction networks, establish standardized and personalized system for integrated traditional Chinese and Western medicine treatment plans, and provide more effective strategies for the prevention and treatment of VMC.