Citation: | YU Kuang, YING Sai, SUN Zheng, SUN Haitian, HONG Run, ZHU Zilong, ZHANG Jianbin. Research Progress on the Mechanism of Action of Moxibustion in the Treatment of Essential Hypertension[J]. Journal of Nanjing University of traditional Chinese Medicine, 2025, 41(5): 609-614. DOI: 10.14148/j.issn.1672-0482.2025.0609 |
This paper systematically sorts out the historical evolution and modern research progress of moxibustion in the treatment of essential hypertension. It analyzes the development of moxibustion in the treatment of hypertension from early experience to the formation of theory, from clinical exploration, initial systematization of clinical research to the current development results, reflecting the scientific and innovative transformation of moxibustion in the treatment of essential hypertension. It reveals that moxibustion can achieve antihypertensive effects through multiple pathways, including neuron-body fluid regulation, renin-angiotensin-aldosterone system regulation, cell signaling pathway regulation, vascular homeostasis, and immune system function regulation, emphasizing its internal consistency from macroscopic syndrome differentiation to microscopic mechanism. Through systematic integration, it can not only highlight the unique advantages of moxibustion in "multi-dimensional adjustment", but also provide a new perspective for breaking through the single-target limitation of current antihypertensive drugs.
[1] |
中国高血压防治指南修订委员会, 高血压联盟(中国), 中国医疗保健国际交流促进会高血压病学分会, 等. 中国高血压防治指南(2024年修订版)[J]. 中华高血压杂志(中英文), 2024, 32(7): 603-700.
China Hypertension Prevention and Treatment Guidelines Revision Committee, Hypertension Alliance (China), Hypertension Branch of China Medical Health International Exchange Promotion Association, et al. Interpretation of the new content of 2024 Chinese guidelines for the management of hypertension: A brief analysis of high-quality antihypertensive strategies focusing on improving blood pressure variation and time in target range of blood pressure[J]. Chin J Hypertens, 2024, 32(7): 603-700.
|
[2] |
ZHOU M, BU H E, WANG D J, et al. An overview of systematic reviews: Acupuncture in the treatment of essential hypertension[J]. Int J Gen Med, 2022, 15: 8093-8109. DOI: 10.2147/IJGM.S387490
|
[3] |
邹冲, 方祝元. 基于"治未病" 理念的中医药全周期防治高血压策略[J]. 南京中医药大学学报, 2024, 40(10): 1129-1135. DOI: 10.14148/j.issn.1672-0482.2024.1129
ZOU C, FANG Z Y. A whole-cycle strategy for preventing and treating hypertension with Chinese medicine based on the concept of "preventive treatment"[J]. J Nanjing Univ Tradit Chin Med, 2024, 40(10): 1129-1135. DOI: 10.14148/j.issn.1672-0482.2024.1129
|
[4] |
李美罗, 李垠和, 吴焕淦, 等. 灸法治疗高血压的研究概述[J]. 环球中医药, 2012, 5(2): 142-147. DOI: 10.3969/j.issn.1674-1749.2012.02.023
LI M L, LI Y H, WU H G, et al. Research summaries of moxibustion therapy on essential hypertension[J]. Glob Tradit Chin Med, 2012, 5(2): 142-147. DOI: 10.3969/j.issn.1674-1749.2012.02.023
|
[5] |
曹晶, 于书庄. 灸百会穴降血压即刻效应的临床观察[J]. 针灸学报, 1991, 7(3): 33-34.
CAO J, YU S Z. Clinical observation on immediate effect of moxibustion at Baihui point on lowering blood pressure[J]. J Clin Acupunct Moxibustion, 1991, 7(3): 33-34.
|
[6] |
陈作霖, 蒋桂素. 艾灸治疗高血压61例[J]. 上海中医药杂志, 1981, 15(7): 30-31.
CHEN Z L, JIANG G S. 61 cases of hypertension treated by moxibustion[J]. Shanghai J Tradit Chin Med, 1981, 15(7): 30-31.
|
[7] |
陆周翔, 嵇冰. 热敏灸对阴虚质、阳虚质两种体质人群正常高值血压的影响[J]. 上海针灸杂志, 2018, 37(1): 97-100.
LU Z X, JI B. Effect of heat-sensitive point moxibustion on high-normal blood pressure in persons with Yin or Yang deficiency[J]. Shanghai J Acupunct Moxibustion, 2018, 37(1): 97-100.
|
[8] |
中华中医药学会心血管病分会. 高血压中医诊疗专家共识[J]. 中国实验方剂学杂志, 2019, 25(15): 217-221.
Society of Cardiovascular Diseases, China Association of Chinese Medicine. Expert consensus on diagnosis and treatment of hypertension with traditional Chinese medicine[J]. Chin J Exp Tradit Med Formulae, 2019, 25(15): 217-221.
|
[9] |
朱国连. 从《黄帝内经》探讨高血压发病与治疗的思路[J]. 中医临床研究, 2014, 6(34): 49-50. DOI: 10.3969/j.issn.1674-7860.2014.34.026
ZHU G L. Treating hypertension from Inner canon of the yellow emperor[J]. Clin J Chin Med, 2014, 6(34): 49-50. DOI: 10.3969/j.issn.1674-7860.2014.34.026
|
[10] |
王冰. 黄帝内经素问[M]. 北京: 人民卫生出版社, 1956.
WANG B. The yellow emperor's inner classic: Basic questions[M]. Beijing: People's Medical Publishing House, 1956.
|
[11] |
李敏. 《千金要方》灸法浅析[J]. 实用中医药杂志, 2009, 25(10): 703-704. DOI: 10.3969/j.issn.1004-2814.2009.10.054
LI M. Analysis on moxibustion method of Qianjin Yaofang[J]. J Pract Tradit Chin Med, 2009, 25(10): 703-704. DOI: 10.3969/j.issn.1004-2814.2009.10.054
|
[12] |
王怀隐. 太平圣惠方: 校点本[M]. 北京: 人民卫生出版社, 2016.
WANG H Y. Formulas from benevolent sages compiled during the Taiping era: Collated and punctuated version[M]. Beijing: People's Medical Publishing House, 2016.
|
[13] |
姜梦笔, 赵梦雅, 黄法, 等. 《本草纲目》中艾叶的考证[J]. 贵州中医药大学学报, 2022, 44(6): 86-91.
JIANG M B, ZHAO M Y, HUANG F, et al. Textual research on Artemisia argyi levl. in "compendium of materia medica"[J]. J Guizhou Univ Tradit Chin Med, 2022, 44(6): 86-91.
|
[14] |
李时珍. 本草纲目[M]. 4版. 北京: 华夏出版社, 2011.
LI S Z. Compendium of materia medica[M]. 4th ed. Beijing: Huaxia Publishing House, 2011.
|
[15] |
雷丰. 时病论[M]. 北京: 中华书局, 2018.
LEI F. Treatise on seasonal diseases[M]. Beijing: Zhonghua Book Company, 2018.
|
[16] |
臧春柳, 佘妙华, 赵见文. 浅析艾灸之原理[J]. 新中医, 2020, 52(19): 133-135.
ZANG C L, SHE M H, ZHAO J W. A brief analysis of theory of moxibustion[J]. J New Chin Med, 2020, 52(19): 133-135.
|
[17] |
LI H G, XIA N. The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness[J]. Redox Biol, 2020, 37: 101585. DOI: 10.1016/j.redox.2020.101585
|
[18] |
MOCTEZUMA S, PEREZ J L, BARABAN E, et al. Cushingsyndrome due to a corticotropin-releasing hormone- and adrenocorticotropic hormone-secreting silent pheochromocytoma[J]. AACE Clin Case Rep, 2024, 10(3): 84-88. DOI: 10.1016/j.aace.2024.01.007
|
[19] |
陈虹屹. 针刺"肝俞"-"太冲"穴对高尿酸血症模型大鼠肝脏XOD、ADA、GD的影响[D]. 北京: 北京中医药大学, 2019.
CHEN H Y. Effect of acupuncture at "Ganshu"-"Taichong" points on liver XOD, ADA and GD in hyperuricemia model rats[D]. Beijing: Beijing University of Chinese Medicine, 2019.
|
[20] |
赵丽, 江钢辉. 艾灸对慢性疲劳综合征模型大鼠的行为及下丘脑-垂体-肾上腺轴激素水平的影响[J]. 山东中医杂志, 2014, 33(4): 301-303.
ZHAO L, JIANG G H. Effects of moxibustion on behavior and hormone levels of hypothalamus-pituitary-adrenergic axis of the model rat with chronic fatigue syndrome[J]. Shandong J Tradit Chin Med, 2014, 33(4): 301-303.
|
[21] |
ZHANG D. Patch clamp: A powerful technique for studying the mechanism of acupuncture[J]. Evid Based Complement Alternat Med, 2012, 2012: 534219. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485550/pdf/ECAM2012-534219.pdf
|
[22] |
张英, 刘又香, 潘克英. 针刺、艾灸、针加灸对肾素-血管紧张素-醛固酮系统、心钠素含量影响的比较研究[J]. 湖北中医学院学报, 2001, 3(2): 20-21, 3. DOI: 10.3969/j.issn.1008-987X.2001.02.008
ZHANG Y, LIU Y X, PAN K Y. Comparison of effects of different acupuncture-moxibustion methods on renin-angiotensin-aldosterone system (RAAS) and atrial natriuretic polypeptide(ANF)[J]. J Hubei Coll Trditional Chin Med, 2001, 3(2): 20-21, 3. DOI: 10.3969/j.issn.1008-987X.2001.02.008
|
[23] |
尹磊, 蒋志明, 杨慧琼, 等. 线粒体基于HUR/PIM1信号通路在高血压血管内皮细胞损伤中的机制[J]. 实用医学杂志, 2022, 38(24): 3043-3048. DOI: 10.3969/j.issn.1006⁃5725.2022.24.004
YIN L, JIANG Z M, YANG H Q, et al. Mechanism of mitochondria-based HUR/PIM1 signaling pathway in hypertensive vascular endothelial cell injury[J]. J Pract Med, 2022, 38(24): 3043-3048. DOI: 10.3969/j.issn.1006⁃5725.2022.24.004
|
[24] |
张新颖, 毛景东, 杨晓燕, 等. AMPK/mTOR信号通路的研究进展[J]. 微生物学杂志, 2019, 39(3): 109-116.
ZHANG X Y, MAO J D, YANG X Y, et al. Advances in AMPK/mTOR signaling path[J]. J Microbiol, 2019, 39(3): 109-116.
|
[25] |
尹柄尊. 基于AMPK/mTOR/ULK1信号通路探讨艾灸调控成骨细胞自噬机制研究[D]. 成都: 成都中医药大学, 2024.
YIN B Z. Study on the mechanism of moxibustion regulating osteoblast autophagy based on AMPK/mTOR/ULK1 signaling pathway[D]. Chengdu: Chengdu University of Traditioinal Chinese Medicine, 2024.
|
[26] |
柳雪蕾, 芦娟, 田叶, 等. 艾灸激活Nrf2/ARE通路抗帕金森病模型大鼠氧化应激损伤的机制研究[J]. 中国针灸, 2020, 40(8): 857-862.
LIU X L, LU J, TIAN Y, et al. Effect and mechanism of moxibustion on oxidative stress injury in rats with Parkinson's disease by activating Nrf2/ARE pathway[J]. Chin Acupunct Moxibustion, 2020, 40(8): 857-862.
|
[27] |
于梦芸. 艾灸及艾烟对APP/PS1双转基因AD小鼠的尿液、血浆靶标代谢组学研究[D]. 北京: 北京中医药大学, 2017.
YU M Y. Metabolomics study on urine and plasma targets of moxibustion and moxa smoke in APP/PS1 double transgenic AD mice[D]. Beijing: Beijing University of Chinese Medicine, 2017.
|
[28] |
张瑞. 艾灸及艾烟调节Rho/ROCK信号通路干预ApoE-/-小鼠动脉粥样硬化的机制研究[D]. 北京: 北京中医药大学, 2020.
ZHANG R. Study on the mechanism of moxibustion and moxa smoke regulating Rho/ROCK signaling pathway to interfere with atherosclerosis in ApoE-/- mice[D]. Beijing: Beijing University of Chinese Medicine, 2020.
|
[29] |
施睿. TRPV1介导的艾灸血管效应的实验研究[D]. 南京: 南京中医药大学, 2016.
SHI R. Experimental study of vascular effects of moxibustion mediated by TRPV1[D]. Nanjing: Nanjing University of Chinese Medicine, 2016.
|
[30] |
岳增辉. 隔药饼灸调节PPAR/TLR双通道延迟动脉粥样硬化形成机制的研究与应用[EB/OL]. (2014-01-22)[2024-10-24]. https://libnew.zcmu.edu.cn/articlesearch/web_searchingDetail?id=20913375776. YUE Z H. Research and application of the mechanism of delaying atherosclerosis formation by moxibustion with medicinal cakes to regulate PPAR/TLR dual channels[EB/OL]. (2014-01-22)[2024-10-24]. https://libnew.zcmu.edu.cn/articlesearch/web_searchingDetail?id=20913375776.
|
[31] |
BONAZ B, SINNIGER V, PELLISSIER S. Therapeuticpotential of vagus nerve stimulation for inflammatory bowel diseases[J]. Front Neurosci, 2021, 15: 650971. DOI: 10.3389/fnins.2021.650971
|
[32] |
YANG T, MAGEE K L, COLON-PEREZ L M, et al. Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats[J]. Acta Physiol (Oxf), 2019, 226(2): e13256. DOI: 10.1111/apha.13256
|
[33] |
ANG Z W, DING J L. GPR41 and GPR43 in obesity and inflammation - protective or causative?[J]. Front Immunol, 2016, 7: 28. http://www.onacademic.com/detail/journal_1000040528841310_944e.html
|
[34] |
LIMA M D C, DO NASCIMENTO H M A, DA SILVA J Y P, et al. Evidence for the beneficial effects of Brazilian native fruits and their by-products on human intestinal microbiota and repercussions on non-communicable chronic diseases-a review[J]. Foods, 2023, 12(18): 3491. DOI: 10.3390/foods12183491
|
[35] |
FENG Y Y, XIA Y F, FAN B K, et al. Global trends and performances of infrared imaging technology studies on acupuncture: A bibliometric analysis[J]. Front Neurosci, 2024, 18: 1387752. DOI: 10.3389/fnins.2024.1387752
|
[36] |
陈宗帅, 尹柏凯, 毛晓波, 等. 智能艾灸设备的精准控温方法[J]. 计算机仿真, 2024, 41(11): 320-326, 480.
CHEN Z S, YIN B K, MAO X B, et al. Accurate temperature control method for intelligent moxibustion equipment[J]. Comput Simul, 2024, 41(11): 320-326, 480.
|
[37] |
李艳, 郭晖, 宋亚刚, 等. 子午流注与生物钟[J]. 中华中医药杂志, 2019, 34(10): 4770-4773.
LI Y, GUO H, SONG Y G, et al. Midday-midnight flowing of qi-blood point and biological clock[J]. China J Tradit Chin Med Pharm, 2019, 34(10): 4770-4773.
|
[38] |
唐三辉, 龚放华. 子午流注配合温灸法改善高血压的疗效观察[J]. 当代护士, 2019, 26(9): 4-6.
TANG S H, GONG F H. Observations on the therapeutic effect of Ziwuliuzhu combined with mild moxibustion in improving hypertension[J]. Today Nurse, 2019, 26(9): 4-6.
|
[39] |
程绍鲁, 叶清景. 生物陶瓷温灸球与艾火隔姜灸的性能比较[J]. 针灸临床杂志, 2003, 19(12): 30-31.
CHENG S L, YE Q J. Performance comparison between bioceramic warm moxibustion ball and moxa fire ginger-isolating moxibustion[J]. J Clin Acupunct Moxibustion, 2003, 19(12): 30-31.
|
[40] |
ZHANG J C, HE J, SHUANG S, et al. Analysis of infrared radiation emitted by moxibustion devices made of different materials using Fourier transform infrared spectroscopy[J]. Heliyon, 2024, 10(12): e33221. DOI: 10.1016/j.heliyon.2024.e33221
|
[41] |
朱德淳, 强晟, 张建斌. 艾灸治疗原发性高血压的疗效特点和作用机制[J]. 上海针灸杂志, 2021, 40(8): 1026-1029.
ZHU D C, QIANG S, ZHANG J B. Therapeutic characteristics and mechanism of moxibustion in the treatment of essential hypertension[J]. Shanghai J Acupunct Moxibustion, 2021, 40(8): 1026-1029.
|
[42] |
WU K Y, ASHKAR S, JAIN S, et al. Breaking barriers in eye treatment: Polymeric nano-based drug-delivery system for anterior segment diseases and glaucoma[J]. Polymers (Basel), 2023, 15(6): 1373. http://www.mdpi.com/2073-4360/15/6/1373#metrics
|
[43] |
LI S Y, CHEN Q L, ZHANG Y L, et al. Hyaluronic acid dissolving microneedle patch-assisted acupoint transdermal delivery of triptolide for effective rheumatoid arthritis treatment[J]. Sci Rep, 2024, 14(1): 25256.
|
[44] |
刘君, 李洁芳. 艾灸联合半夏白术天麻汤治疗痰湿质高血压伴颈动脉粥样硬化的临床观察[J]. 中医药导报, 2020, 26(1): 69-71, 78.
LIU J, LI J F. Clinical observation of moxibustion combined with Banxia Baizhu Tianma decoction in treating phlegm-dampness hypertension with carotid atherosclerosis[J]. Guid J Tradit Chin Med Pharm, 2020, 26(1): 69-71, 78.
|
[45] |
冯婷, 李伟佳. ACEI类药物高血压治疗的临床疗效[J]. 中国实用医药, 2015, 10(25): 194-195.
FENG T, LI W J. Clinical efficacy of ACEI drugs in the treatment of hypertension[J]. China Pract Med, 2015, 10(25): 194-195.
|
[46] |
曾文艳. 艾灸治疗阳虚证充血性心力衰竭的临床疗效观察[D]. 广州: 广州中医药大学, 2015.
ZENG W Y. Clinical observation on moxibustion in treating congestive heart failure with Yang deficiency syndrome[D]. Guangzhou: Guangzhou University of Chinese Medicine, 2015.
|
[47] |
KOLD S, GRAVEN-NIELSEN T. Effect of anodal high-definition transcranial direct current stimulation on the pain sensitivity in a healthy population: A double-blind, sham-controlled study[J]. Pain, 2021, 162(6): 1659-1668.
|
[48] |
廖颖, 蒋晶, 熊坚, 等. 虚拟现实技术在针灸领域应用现状与热点分析[J]. 中医康复, 2024, 15(3): 49-54.
LIAO Y, JIANG J, XIONG J, et al. Analysis of the current situation and hotspots of the application of virtual reality technology in the field of acupuncture[J]. Tradit Chin Med Rehabil, 2024, 15(3): 49-54.
|
[49] |
李敏琤, 冯青根, 俞璐, 等. 中医药治疗轻度认知功能障碍研究述评[J]. 河南中医, 2018, 38(10): 1522-1526.
LI M C, FENG Q G, YU L, et al. A review of traditional Chinese medicine for mild cognitive impairment[J]. Henan Tradit Chin Med, 2018, 38(10): 1522-1526.
|