KONG Ziyang, WU Liang, LI Wen, HAN Jie, SHENG Chenmin, LIAN Yuheng, MENG Lingdong, ZHAO Yunan, BIAN Yaoyao. Analysis of Chemical Components of Suanzaoren Decoction and Components Absorbed into Blood of Female Rats Based on UHPLC-Q Exactive Orbitrap-MS[J]. Journal of Nanjing University of traditional Chinese Medicine, 2025, 41(3): 375-382. DOI: 10.14148/j.issn.1672-0482.2025.0375
Citation: KONG Ziyang, WU Liang, LI Wen, HAN Jie, SHENG Chenmin, LIAN Yuheng, MENG Lingdong, ZHAO Yunan, BIAN Yaoyao. Analysis of Chemical Components of Suanzaoren Decoction and Components Absorbed into Blood of Female Rats Based on UHPLC-Q Exactive Orbitrap-MS[J]. Journal of Nanjing University of traditional Chinese Medicine, 2025, 41(3): 375-382. DOI: 10.14148/j.issn.1672-0482.2025.0375
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Analysis of Chemical Components of Suanzaoren Decoction and Components Absorbed into Blood of Female Rats Based on UHPLC-Q Exactive Orbitrap-MS

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    • Abstract
  • Objective To analyze the blood components of Suanzaoren Decoction after oral administration using UHPLC-Q Exactive Orbitrap-MS technology.
    Methods Female Sprague-Dawley (SD) rats were used as experimental subjects, and Suanzaoren Decoction was administered orally. Serum samples were collected, and the aqueous extract of Suanzaoren Decoction and the serum were analyzed using UHPLC-Q Exactive Orbitrap-MS technology to identify the prototype components and metabolites absorbed into the blood by comparing and analyzing with the LuMet-TCM database.
    RESULTS It showed that a total of 458 components were identified in the aqueous extract of Suanzaoren Decoction, and 26 chemical components were identified in the blood, including 23 prototype components and 3 metabolites.
    CONCLUSION The prototype components absorbed into the blood discovered in this study may be the active ingredients of Suanzaoren Decoction, providing a reference for the research on the pharmacodynamic material basis of Suanzaoren Decoction.
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