Clinical Study on Huangjing Jiangya Decoction in the Treatment of Patients with Hypertension of Qi-Deficiency Type Accompanied by Insomnia

OBJECTIVE To observe the effect of Huangjing Jiangya Decoction on blood pressure and sleep in patients with hypertension of qi-deficiency type accompanied by insomnia.

METHODS 73 patients with hypertension of qi-deficiency type accompanied by insomnia who met the inclusion criteria were selected and randomly divided into an observation group of 36 cases and a control group of 37 cases. The control group was treated with amlodipine besylate tablets, and the observation group was given Huangjing Jiangya Decoction oral treatment on the basis of the control group. Both groups were treated continuously for 8 weeks. The changes in TCM syndrome scores, office blood pressure monitoring (OBPM), home blood pressure monitoring (HBPM), 24-hour ambulatory blood pressure monitoring (ABPM), Pittsburgh Sleep Quality Index (PSQI) scores and clinical efficacy of the two groups of patients before and after treatment were observed.

RESULTS After treatment, the TCM syndrome scores in the observation group were significantly decreased (P < 0.05, P < 0.01), which were better than the control group (P < 0.01); OBPM and HBMP in both groups were significantly reduced (P < 0.05, P < 0.01), the observation group was better than the control group (P < 0.05, P < 0.01); the ABPM of the observation group was significantly reduced (P < 0.01), which was better than the control group (P < 0.05, P < 0.01); the sleep quality, sleep latency, sleep duration, daytime dysfunction score and PSQI total score of the observation group were significantly decreased (P < 0.01), which were better than those in the control group (P < 0.05, P < 0.01); the clinical efficacy of hypertension and insomnia in the observation group was both better than the control group (P < 0.01).

CONCLUSION Huangjing Jiangya Decoction combined with amlodipine can improve the symptoms of patients with hypertension of qi-deficiency type accompanied by insomnia, lower blood pressure, improve sleep quality, shorten sleep latency, alleviate daytime dysfunction, and has good clinical efficacy.