HUANG Senlan, ZHU Xixi, LU Shanshan, SONG Zhichao, DONG Jie, WANG Yiwei, CHEN Jun. Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(5): 503-509. DOI: 10.14148/j.issn.1672-0482.2024.0503
Citation: HUANG Senlan, ZHU Xixi, LU Shanshan, SONG Zhichao, DONG Jie, WANG Yiwei, CHEN Jun. Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine[J]. Journal of Nanjing University of traditional Chinese Medicine, 2024, 40(5): 503-509. DOI: 10.14148/j.issn.1672-0482.2024.0503
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Research on the Correlation Between Transepidermal Glycoside Penetration Enhancement Effect and Transepidermal Water Loss Values of Essential Oils from Traditional Chinese Medicine

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    • Abstract
  •   OBJECTIVE  To study the correlation between penetration enhancement effect and transepidermal water loss (TEWL) values of essential oils (EOs) from traditional Chinese medicine (TCM).
      METHODS  The amount of 3 kinds of glycosides(geniposide, gentiopicroside, paeoniflorin)and their oil-water partition coefficient were determined by HPLC. The penetration enhancement effect of the five EOs from Gaoliangjiang (Alpiniae Officinarum Rhizoma, AOR), Ganjiang (Zingiberis Rhizoma, ZR), Bohe (Menthae Haplocalycis Herba, MHH), Hujiao (Piperis Fructus, PF) and Wuzhuyu (Euodiae Fructus, EF) on geniposide, gentiopicroside, and paeoniflorin were performed by the modified Franz diffusion cell method with the abdominal skin of rats. The TEWL values were measured to evaluate the effect of the five EOs on the skin barrier function of rats. The correlation between penetration enhancement effect of EOs and their effect on skin barrier function was investigated by correlation analysis.
      RESULTS  AOR oil, ZR oil, MHH oil, and PF oil could improve the absorption of the three glycosides and reduce skin barrier function of rats. The results of correlation analysis showed that the penetration enhancement effect of EOs was significantly related to TEWL values following dermal administration of EOs.
      CONCLUSION  TEWL measurement technology provides a more convenient method for the selection of penetration enhancers.
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