JI Wei-peng, YANG Yan, LI Kun, JI Yu, TIAN Zu-cheng, DAI Hai-feng, CHEN An, GE Fei. Clinical Efficacy of Jieyu Fuwei Powder Combined with Acupoint Catgut Embedding in the Treatment of Syndrome Functional Dyspepsia with Liver and Stomach Disharmony and Its Impact on Brain-Gut Peptides[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(8): 783-787. DOI: 10.14148/j.issn.1672-0482.2023.0783
Citation: JI Wei-peng, YANG Yan, LI Kun, JI Yu, TIAN Zu-cheng, DAI Hai-feng, CHEN An, GE Fei. Clinical Efficacy of Jieyu Fuwei Powder Combined with Acupoint Catgut Embedding in the Treatment of Syndrome Functional Dyspepsia with Liver and Stomach Disharmony and Its Impact on Brain-Gut Peptides[J]. Journal of Nanjing University of traditional Chinese Medicine, 2023, 39(8): 783-787. DOI: 10.14148/j.issn.1672-0482.2023.0783
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Clinical Efficacy of Jieyu Fuwei Powder Combined with Acupoint Catgut Embedding in the Treatment of Syndrome Functional Dyspepsia with Liver and Stomach Disharmony and Its Impact on Brain-Gut Peptides

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    • Abstract
  •   OBJECTIVE  To study the clinical efficacy of Jieyu Fuwei Powder combined with acupoint catgut embedding in the treatment of functional dyspepsia (FD) with liver and stomach disharmony and its impact on brain gut peptides.
      METHODS  62 cases of FD patients with chronic liver and stomach disharmony were enrolled in the digestive department and acupuncture and moxibustion department of Hai'an Hospital of Chinese Medicine, and were randomly divided into a control group and a treatment group, with 31 cases in each group (1 case dropped out of the control group). The control group was orally treated with mosapride citrate, and the treatment group was treated with Jieyu Fuwei Powder combined with acupoint catgut embedding. The clinical efficiency of the two groups was compared. Before and after treatment, the TCM syndrome score, modified severity of dyspepsia assessment (mSODA) score of the two groups of patients were observed, and serum levels of brain-gut peptides Calcitonin gene related peptide (CGRP), Substance P (SP), Motilin (MTL), and Gastrin (GAS) were detected. During the treatment, the adverse reactions of the two groups of patients were observed.
      RESULTS  After treatment, the total effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). The TCM syndrome scores of bilateral fullness, epigastric fullness, pain, and belching, as well as mSODA scores of the two groups of patients were improved compared to those before treatment (P < 0.05, P < 0.01), and the treatment group showed better efficacy than the control group (P < 0.05, P < 0.01). The levels of serum CGRP and SP in the two groups of patients were significantly decreased (P < 0.01), with average significant increases in MTL and GAS(P < 0.01), and the treatment group displayed better improvement than the control group (P < 0.05, P < 0.01). The incidence of adverse reactions in the treatment group was lower than that in the control group (P < 0.05).
      CONCLUSION  Jieyu Fuwei Powder combined with acupoint catgut embedding is more effective than mosapride citrate group in the treatment of FD with liver and stomach disharmony, and its mechanism may be related to the regulation of brain-gut peptides.
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