OBJECTIVE To evaluate the clinical efficacy of traditional Chinese medicine combined with hormone non-tailing therapy in the treatment of children with refractory nephrotic syndrome (RNS).
METHODS A total of 122 children with RNS who were treated in the hospital from June 2019 to June 2022 were divided into an observation group and a control group according to the random number table method, with 60 cases in the observation group and 62 cases in the control group.The control group was given prednisone tablets combined with tacrolimus treatment, of which prednisone tablets were treated with tailing therapy.On the basis of the control group, the observation group was additionally treated with traditional Chinese medicine (sequential syndrome differentiation of Yiqi Huayu Qingre Decoction), among which the prednisone tablets were treated with non-tailing therapy.To compare the total cumulative amount of hormones, hormone side effects, total effective rate and recurrence rate after 52 weeks of treatment.The changes of 24 h urine protein quantification (24 h UTP), plasma albumin (ALB), and blood lipidstotal cholesterol (TC) and triglyceride (TG)before treatment and after 4 weeks, 12 weeks and 24 weeks of treatment were compared.The changes of liver and kidney function, i.e., alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and serum creatinine (SCr) before treatment and after 24 weeks of treatment were compared.Observe the changes in the scores of the Chinese medicine life quality evaluation scale in children with refractory nephropathy before treatment and after 24 weeks of treatment.
RESULTS After 4 weeks, 12 weeks and 24 weeks of treatment, 24 h UTP, ALB, TC and TG in the two groups were improved compared with those before treatment, and the improvement in the observation group was more obvious (P < 0.05, P < 0.01).There was no significant change in ALT, AST, BUN and SCr in the two groups before and after 24 weeks of treatment (P>0.05).After 24 weeks of treatment, the scores of TCM syndromes in the two groups were significantly decreased (P < 0.05, P < 0.01), and the total scores of TCM quality of life scale were significantly increased (P < 0.01), and the observation group was better than the control group (P < 0.05, P < 0.01).After 52 weeks of treatment, the total cumulative amount of hormones in the observation group was lower than that in the control group (P < 0.01), and the side effects of hormones were less than those in the control group (P < 0.01).The total effective rate was higher than that of the control group (P < 0.05), and the recurrence rate was lower than that of the control group (P < 0.05).
CONCLUSION Traditional Chinese medicine combined with hormone non-tailing therapy is effective in the treatment of children with RNS.It can increase plasma albumin, reduce the urine protein, and blood lipids, and improve the life quality of RNS children.
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