Clinical Study of Curative Effect of Bikangfu Nasal Tamponade on Acute Rhinosinusitis

  OBJECTIVE  To observe the effects of Bikangfu nasal tamponade on acute rhinosinusitis, inflammatory factors, inflammation-related proteins and neuropeptides in serum and nasal secretions.

  METHODS  144 cases were randomly divided into the control group and observation group (n=72). On the basis of conventional treatment the control group was given mometasone furoate, and the observation group was treated with Bikangfu nasal tamponade. The nasal situation Lund-Kennedy (Lund-Kennedy) and sinus nasal outcome test-20 (SNOT-20) were used, and the nasal airway resistance (NAR) and TCM symptoms were observed before and after treatment. The nasal ciliary clearance function, including mucosal ciliary clearance rate (MCC), mucociliary transport rate (MTR), and saccharin clearance time (SCT), was tested. The inflammatory factors leukotriene C₄ (LTC₄), interleukin 17 (IL-17), prostaglandin D₂ (PGD₂), inflammation-related proteins eosinophil cationic protein (ECP), aquaporin-3 (AQP-3), immunoglobulin E (IgE), and neuropeptides substance P (SP), neurokinin A (NKA), neuropeptide Y (NPY) in serum and nasal secretions were detected.

  RESULTS  After treatment, the TCM symptoms, Lund-Kennedy score, SNOT-20 score, NAR, SCT, LTC₄, IL-17, PGD₂, ECP and IgE of the two groups were decreased (P < 0.05, P < 0.01), and MTR, MCC, AQP-3, SP, NKA and NPY of the two groups were increased (P < 0.05, P < 0.01). Moreover, the observation group displayed better therapeutic effects than the control group (P < 0.05, P < 0.01). The clinical total effective rate of TCM in the observation group was significantly higher than that in the control group (P < 0.05).

  CONCLUSION  Bikangfu nasal tamponade can remit the clinical symptoms of patients with acute rhinosinusitis, and the mechanism of the action may be related to regulating inflammatory factors, inflammation-related proteins and neuropeptides in serum and nasal secretions.