Exploration of the Prescription Rule of Kaichi Prescription and Anti-Inflammation Mechanism of the Core Prescription in Compilations of Chinese Medical Formulae Recorded by Imperial Court: Oral Medicine Based on the Excavation of Ancient Literature and Network Pharmacology

  OBJECTIVE  To excavate the medication rule of Kaichi prescription in Compilations of Chinese Medical Formulae Recorded by Imperial Court: Oral Medicine and analyze the anti-inflammation mechanism of core prescription.

  METHODS  Collect and organize the Kaichi prescription in Compilations of Chinese Medical Formulae Recorded by Imperial Court: Oral Medicine and perform descriptive statistical analysis, analysis of high-frequency Herb pairs and Herb groups, and analysis of core prescription and anti-inflammation mechanism of core prescription.

  RESULTS  A total of 102 Kaichi prescriptions were collected, mainly for the treatment of gingival diseases, with 33 kinds of high-frequency Herbs with a frequency of more than 5, such as Radix et Rhizoma Asari, Rhizoma Cimicifugae, Fructus Gleditsiae, Halitum, Moschus, etc. Forty-six drug pairs and drug groups were obtained by association rule analysis, and the core prescription with herbs composition of Rhizoma Cimicifugae, Radix Angelicae Dahuricae, Radix et Rhizoma Asari and Rhizoma Ligustici was found. The active ingredients of the core prescription, including kaempferol and byakangelicol, can affect lipid and atherosclerosis, pathways in cancer and kaposi sarcoma-associated herpesvirus infection acting on targets such as PTGS2, PIK3CA and MAPK8 to treat inflammation.

  CONCLUSION  The Kaichi prescription makes good use of wind medicine, focusing on dispelling wind and relieving pain, aromatic deodorization, as well as clearing heat and reducing internal heat. The core prescription has the characteristics of multi-components, multi-targets and multi-pathways in the treatment of inflammation.