OBJECTIVE To observe the effects of Qinggan Zishen formula combined with conventional antihypertensive western medicine treatment on the expression level of irisin and metabolic indexes in patients with obesity-related hypertension.
METHODS A total of 80 obesity-related hypertension patients with yin deficiency and yang hyperactivity who met the inclusion criteria were selected and randomly divided into 40 cases each in the observation group and the control group. In the control group, patients were given lifestyle interventions and continuous conventional western medical treatment, while the observation group was treated with oral administration of traditional Chinese medicine (TCM) decoction pieces - Qinggan Zishen formula based on the therapies in the control group. The treatment course lasted eight weeks. In addition, before and after the treatment, we observed the changing levels of TCM syndrome score, clinical efficacy, anthropometric indexes systolic blood pressure (SBP), diastolic blood pressure (DBP), weight (WT), waist circumference (WC), metabolic indexes fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), irisin, adipokines adiponectin (ADP) and leptin (LEP), as well as safety indicators.
RESULTS After treatment, the TCM syndrome scores of both groups were decreased significantly (P < 0.05, P < 0.01), but the result of observation group was better than that of control group in reliving the syndromes of headache and dizziness, irritability, tidal fever and night sweats, soreness and weakness of waist and knees, dry mouth and throat, feverish sensations in palms, soles and chest, constipation, as well as dark urine. Besides, the total TCM syndrome scores of observation group showed better results than those of the control group (P < 0.05, P < 0.01). In addition, the TCM clinical efficacy of the observation group was better than that of the control group (P < 0.05). The irisin level was significantly higher in the observation group (P < 0.01), so its result was better than that of the control group (P < 0.01). The levels of SBP and DBP were significantly reduced in the observation group (P < 0.05), which also showed better results than those of the control group (P < 0.05). Although both groups' results of WT, WC, TC, TG, LDL-C, ADP, and LEP were notably changed in a good way (P < 0.05, P < 0.01), the observational group showed better results than those of the control group (P < 0.05). No significant adverse reactions were observed in both groups during the treatment course.
CONCLUSION Qinggan Zishen formula combined with conventional antihypertensive western medicine can regulate irisin expression and mitigate metabolic disorders in obesity-related hypertension patients with yin deficiency and yang hyperactivity.
DownLoad: