OBJECTIVE To observe the clinical efficacy of the supplemented Shenling Baizhu Powder on the microinflammatory state in patients of spleen deficiency and turbidity obstruction treated with continuous ambulatory peritoneal dialysis (CAPD) combined with suffering from protein-energy wasting (PEW).
METHODS A total of 91 patients of spleen deficiency and turbidity obstruction treated with CAPD combined with suffering from PEW were randomly divided into 45 cases in the treatment group and 46 cases in the control group, with shedding three cases in each group. The control group's treatments include CAPD, orally taken compound alpha ketoacid, and other conventional therapies. However, the treatment group was administrated with the supplemented Shenling Baizhu powder by orally taken on the basis of the treatments in the control group. The course of treatment was 12 weeks in both groups. Before and after treatment, we observed the changes in the traditional Chinese medicine (TCM) syndrome score, malnutrition-inflammation score (MIS) and overall urea clearance index scores (Kt/V) of the two groups of patients. In addition, we measured the patients' peripheral blood nutrition-related indexes hemoglobin (HGB), albumin (ALB), transferrin (TRF), prealbumin (PA), as well as the levels of microinflammatory indexes interleukin-6 (IL-6), hypersensitive c-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10).
RESULTS After treatment, the TCM syndrome score in the treatment group was reduced significantly (P < 0.01), whose result was better than that in the control group (P < 0.01). In addition, the total clinical efficacy of TCM in the treatment group was remarkably better than that in the control group (P < 0.05). The MIS in the treatment group was reduced significantly but with significantly increased Kt/V (P < 0.01), whose results were also better than those in the control group (P < 0.05, P < 0.01). At the same time, ALB, PA, TRF and HGB levels were significantly increased in the treatment group (P < 0.01), while only ALB and PA levels were significantly increased in the control group (P < 0.01). Thus, the results in the treatment group were better than those in the control group (P < 0.05, P < 0.01). On top of that, serum hs-CRP, IL-6 and TNF-α levels were significantly reduced in both groups (P < 0.01), and IL-10 levels were increased in two groups (P < 0.05, P < 0.01). In conclusion, the results in the treatment group were superior to those in the control group (P < 0.05, P < 0.01).
CONCLUSION The supplemented Shenling Baizhu powder can notably alleviate the TCM syndromes in patients of spleen deficiency and turbidity obstruction treated with CAPD combined with suffering from PEW. In addition, it can relieve their PEW, alleviate the microinflammatory state, and strengthen the adequacy of peritoneal dialysis.
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