Clinical Study on the Effect of Qianyang Yuyin Granules on Vascular Elasticity Function of Hypertension Combined with Hyperlipidemia with Yin Deficiency and Yang Excess Syndrome

OBJECTIVE  To investigate the clinical efficacy of Qianyang Yuyin granules on carotid artery vascular elasticity function in patients with yin-deficiency-yang-excess hypertension combined with hyperlipidemia.METHODS  A total of 80 patients with yin-deficiency-yang-excess hypertension combined with hyperlipidemia who met the inclusion criteria were randomly divided into observation group and control group, 40 cases each. In the control group, calcium antagonist amlodipine and atorvastatin calcium tablets were given as standard treatment. While in the observation group, Qianyang Yuyin granules were given on the basis of the treatment in the control group with a 12-week treatment course. In addition, we observed the traditional Chinese medicine (TCM) syndrome score and clinical efficacy, blood pressure and cholesterol level low density lipoprotein (LDL), high density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), inflammation C-reactive protein (CRP), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), coagulation indexes activated partial thromboplastin time (APTT), prothrombin time (PT), hemodynamic indexes whole blood high shear viscosity, whole blood medium shear viscosity, whole blood low shear viscosity, erythrocyte sedimentation rate (ESR), carotid intima-media thickness (cIMT), ultrafast imaging pulse wave velocity bilateral carotid artery beginning-systolic pulse wave velocity (PWV-BS), end-systolic pulse wave velocity (PWV-ES) and safety indicators.RESULTS  After treatment, the TCM syndrome score and clinical efficacy improved in both groups, while the results in the observation group were better than those in the control group (P < 0.05). The treatments in both groups showed blood pressure-reducing effects (P < 0.01). LDL, HDL, TC, TG, CRP, IL-6, TNF-α, APTT, PT, whole blood high shear viscosity, whole blood medium shear viscosity, whole blood low shear viscosity, ESR were all improved in the two groups (P < 0.05, P < 0.01). In the observation group, the results of TC, LDL, TNF-α, APTT and ESR were better than those in the control group (P < 0.05, P < 0.01). In addition, PWV-BS and PWV-ES improved in both groups (P < 0.05, P < 0.01).CONCLUSION  Combining basic treatment with Qianyang Yuyin granules can improve the clinical efficacy of hypertension combined with hyperlipidemia in patients with yin deficiency and yang hyperactivity, reduce blood pressure and lipid level, and improve inflammation status, coagulation function, blood rheology, as well as arterial elasticity function.