Volume 37 Issue 5
Sep.  2021
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CHEN Jun, YAO Jun-hong, WANG Yi-wei, GU Wei, YAN Guo-jun, ZHANG Xiao-dong, DUAN Jin-ao. "Compound-Delivery-Efficacy" Characterization Idea of External Chinese Medical Properties Based on Biopharmaceutical Thoughts[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(5): 654-657. DOI: 10.14148/j.issn.1672-0482.2021.0654
Citation: CHEN Jun, YAO Jun-hong, WANG Yi-wei, GU Wei, YAN Guo-jun, ZHANG Xiao-dong, DUAN Jin-ao. "Compound-Delivery-Efficacy" Characterization Idea of External Chinese Medical Properties Based on Biopharmaceutical Thoughts[J]. Journal of Nanjing University of traditional Chinese Medicine, 2021, 37(5): 654-657. DOI: 10.14148/j.issn.1672-0482.2021.0654
shu

"Compound-Delivery-Efficacy" Characterization Idea of External Chinese Medical Properties Based on Biopharmaceutical Thoughts

  • 1.

    Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 2.

    Collaborative Innovation Center for the Industrialization Process of Traditional Chinese Medicine Resources in Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing, 210023, China

  • 3.

    School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China

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  • Received Date: September 19, 2021
  • Available Online: December 20, 2021
  • Published Date: September 09, 2021
    Graphical Abstract
    • Abstract
  • Characterization of Chinese medical properties is the key basis for guiding modern study in drug property discovery. However, lack of appropriate guidance limits current studies of external Chinese Medicine(CM). Based on the study progress of Chinese medical properties and the characteristics of external CM, three key elements of "component-delivery-efficacy" are proposed based on biopharmaceutical thoughts. Using such characterization model, drug delivery can be firstly regarded as the key factor between the component and the efficacy under the external route. Under the guidance of "compound-delivery-efficacy", essential oils (EOs) from herbs with "hot" property was found to possess higher penetration enhancement effect compared to other properties. The results revealed the rationale of the proposed three-element theory. This theory may lead a new strategy in scientific research, clinical application, and development of external CM products.
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    • References (33)
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