The Effect of Yinjia Pellet on the Short Term Efficacy and Long Term Recurrence Rate of Treating Graves' Hyperthyroidism

OBJECTIVE  To discuss the effect of Yinjia pellet on the short term efficacy and long term recurrence rate of treating hyperthyroidism in diffuse goiter (Graves' disease).METHODS  80 patients with Graves' disease and hyperthyroidism in Jiangsu Hospital of traditional Chinese medicine were randomly divided into two groups by SAS system. The treatment group was given Yinjia pellet combined with western medicine while the control group was only given western medicine. After six-month course, the short term efficacy was observed. We followed up the patients for two years after the treatment and estimated the recurrence rate.RESULTS  After treatment, the degree of proptosis and traditional Chinese medicine syndrome scores in the two groups were improved (P < 0.01), and the treatment group was better than the control group (P < 0.05, P < 0.01). The levels of total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), and thyrotrophin receptor antibody (TRAb) were improved (P < 0.05, P < 0.01), which in the treatment group were better than those in the control group (P < 0.05, P < 0.01) and took less time to recover than those in the control group (P < 0.01). The total efficacy rate in the treatment group was higher than that of the control group (P < 0.01). With the two-year follow-up, it was found that the recurrence rate in the treatment group was lower than that in the control group (P < 0.05).CONCLUSION  Yinjia pellet combined with Western medicine has more significant effect on treating hyperthyroidism of Graves' disease, which can reduce the recovery duration of thyroid function and the recurrence rate of hyperthyroidism.