清肾颗粒对慢性肾衰竭患者肾功能及血清α-平滑肌动蛋白和E-钙粘蛋白的影响

张磊; 金华; 王亿平; 王东; 文艳; 刘珂

清肾颗粒对慢性肾衰竭患者肾功能及血清α-平滑肌动蛋白和E-钙粘蛋白的影响

张磊¹,
金华²,
王亿平²,
王东²,
文艳¹,
刘珂¹

1.
安徽中医药大学研究生院，安徽合肥 230038
2.
安徽中医药大学第一附属医院，安徽合肥 230031

计量
- 文章访问数: 685
- HTML全文浏览量: 2
- PDF下载量: 424
- 被引次数: 0
出版历程
- 刊出日期: 2019-11-10

A Clinical Study on the Effect of Qingshen Capsule on Chronic Kidney Failure Patients' Kidney Function， Serum α-Smooth Muscle Actin and E-Cadherin

1.
Graduate School, Anhui University of Chinese Medicine, Hefei, 230038, China
2.
The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230031, China

摘要

摘要: 目的观察中药复方清肾颗粒对于慢性肾衰竭湿热证患者肾功能及血清α-平滑肌动蛋白和E-钙粘蛋白的影响。方法符合纳入标准的70例慢性肾衰竭湿热证患者，随机分为治疗组和对照组各35例，治疗组在对照组治疗方案基础上加用清肾颗粒口服，疗程12周。观察2组中医证候疗效及临床疗效；治疗前后血肌酐（Scr）、肾小球滤过率（eGFR）、血清α-平滑肌动蛋白（α-SMA）、E-钙粘蛋白(E-cadherin)水平变化。结果研究最终完成68例（治疗组、对照组各34例）。治疗后治疗组中医证候疗效及临床疗效均优于对照组（P<0.05）；治疗组患者Scr、eGFR水平明显改善(P<0.05)，优于对照组(P<0.05)；治疗组血清α-SMA、E-cadherin水平下降（P<0.05），比对照组低（P<0.05）；治疗组患者服用清肾颗粒后未出现药物不良副作用。结论清肾颗粒能够减轻慢性肾衰竭湿热证患者临床症状，降低Scr水平，同时下调慢性肾衰竭湿热证患者血清α-SMA、E-cadherin水平，安全性良好。
- 慢性肾衰竭 /
- 湿热证 /
- 清肾颗粒 /
- α-平滑肌动蛋白 /
- E-钙粘蛋白
Abstract: OBJECTIVE To observe the effect of Chinese herbal compound Qingshen capsule on chronic kidney failure patients' kidney function， serum α-smooth muscle actin (α-SMA)and E-cadherin. METHODS 70 chronic kidney failure patients with dampness-heat syndrome were randomly divided into the treatment group and the control group with35 in each. Based on the therapy for the control group， the treatment group was also given Qingshen capsule. The course lasted 12 weeks. After that， 68 patients completed the follow-up， each group 34 cases. The observing parameters included curative effect of traditional Chinese medicine (TCM) syndrome， clinical effect， the level of serum creatinine (Scr)，e-GFR serum α-SMA and E-cadherin before and after treatment. RESULTS After treatment， TCM syndrome effect and clinical effect of the treatment group was better than that of the control group (P<0.05). As for the level of Scr and eGFR， patients in the treatment group has much improved (P<0.05) than those in the control group (P<0.05). The level of serum α-SMA and E-cadherin declined (P<0.05)， lower than that of control group (P<0.05). Patients in the treatment group hadn't been exposed to the side effects of Qingshen capsule. CONCLUSION Qingshen capsule can relive clinical symptoms for chronic kidney failure patients with dampness-heat syndrome， more precisely， degrading Scr level， serum α-SMA and E-cadherin and having good safety.
- chronic kidney failure /
- dampness-heat syndrome /
- Qingshen capsule /
- α-smooth muscle actin /
- E-cadherin

HTML全文

参考文献(4)

[1]	王善志，朱永俊，李国铨，等.中国成人慢性肾脏病患病率的Meta分析结果及对比 [J]．中华肾脏病杂志，2018，34(8):579-586.
[2]	ZHONG Y，MENON MC，DENG Y，et al. Recent advances in traditional Chinese medicine for kidney disease[J]. Am J Kidney Dis， 2015，66(3):513-522.
[3]	李文娟，王亿平.湿热证与慢性肾衰竭病证关系浅析[J].安徽中医学院学报，2004，23(2):58-59.
[4]	王亿平，王东，李传平，等.清热化湿祛瘀法对慢性肾衰竭湿热证患者多中心随机对照的临床研究[J].北京中医药大学学报，2016，39(9):774-778.