益气养阴通络方对早期糖尿病肾病微炎症状态的影响

窦晨辉; 陈晓虎; 彭书玲

益气养阴通络方对早期糖尿病肾病微炎症状态的影响

1.
郑州人民医院中医科，河南郑州 450000
2.
南京中医药大学附属医院，江苏南京 210029

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出版历程
- 刊出日期: 2019-03-10

The Effect of Yiqi Yangyin Tongluo Formula on Micro-Inflammatory State of Patients with Early Diabetic Nephropathy

1.
Department of TCM, People's Hospital of Zhengzhou, Henan, 450000, China
2.
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China

摘要

摘要: 目的探讨益气养阴通络方对早期糖尿病肾病微炎症状态的影响。方法将患者随机分2组各39例，对照组给予常规基础治疗，治疗组在对照组基础上加用益气养阴通络方，12周后比较2组C反应蛋白（CRP）、肿瘤坏死因子（TNF-α）、尿白蛋白排泄率（UAE）及临床疗效、中医证候积分、血压、血糖、尿素氮（BUN）、肌酐（Scr）等指标变化。结果治疗组总有效率及中医证候积分改善情况优于对照组（P<0.05）；与治疗前相比，2组治疗后UAE、CRP、TNF-α水平均降低（P<0.05~0.01），治疗组改善幅度优于对照组（P<0.05）；观察过程均未出现肾功能恶化。结论益气养阴通络方能改善早期糖尿病肾病患者的症状，降低炎症因子CRP、TNF-α水平，减少蛋白尿，对早期糖尿病肾病的微炎症状态有明显的干预作用，从而延缓了糖尿病肾病进展。
- 糖尿病肾病 /
- 微炎症状态 /
- 益气养阴通络方
Abstract: OBJECTIVE To explore the effect of Yiqi Yangyin Tongluo formula on micro inflammatory state of patients with early diabetic nephropathy. METHODS 78 patients were randomly divided into two groups with 39 patients in each group. The control group was given conventional basic treatment， and the treatment group was treated with Yiqi Yangyin Tongluo formula on the basis of the control group. After 12 weeks， the changes of C-reactive protein (CRP)， tumor necrosis factor (TNF-α)， urinary albumin excretion rate (UAE) and clinical efficacy， TCM syndrome score， blood pressure， blood glucose， urea nitrogen (BUN)， creatinine (Scr) and other indicators in two groups were compared. RESULTS The total effective rate and TCM syndrome score improvement in the treatment group were better than those in the control group (P<0.05). Compared with pre-treatment， the levels of UAE， CRP and TNF-α in the two groups were lower (P<0.05， P<0.01)， and the improvement in the treatment group was better than that in the control group (P<0.05). No renal deterioration appeared during the observation process. CONCLUSION Yiqi Yangyin Tongluo formula can improve the symptoms of patients with early diabetic nephropathy， reduce the levels of inflammatory factors CRP， TNF-α， reduce proteinuria， and significantly interfere with the micro inflammation of early diabetic nephropathy， thus delaying the progression of diabetic nephropathy.
- diabetic nephropathy /
- micro-inflammatory state /
- Yiqi Yangyin Tongluo formula

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参考文献(14)

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